外周神经损伤后再生的相关信号通路

Signal pathways related to regeneration after peripheral nerve injury

由于神经元损伤后的自身再修复能力有限,临床上对于神经损伤一直缺乏有效的治疗手段,因此,寻找促进神经损伤后修复的药物,以及探索其相关作用机制始终是神经科学领域的研究热点。有研究表明,在外周神经组织中,神经元细胞和雪旺细胞内的信号通路对于外周神经损伤后再生有着重要作用。本文综述了雪旺细胞和神经元内与外周神经再生相关的信号通路以及与外周神经损伤相关的疾病,为进一步探索外周神经损伤后再生机制提供依据。

Due to the limited self-repair ability of neurons after injury,there has been a lack of effective treatments for nerve injury in clinical practice.So,to find drugs that promote the repair after nerve injury has become a research hotspot.Schwann cells and neurons play an important role in regeneration of the peripheral nerves after injury.This review summarizes the classification of peripheral nerve injury,the signaling pathways related to peripheral nerve regeneration in Schwann cells and neurons as well as diseases related to peripheral nerve injury,and provides a basis for further exploration of the regeneration mechanism after peripheral nerve injury.