硫普罗宁联合谷胱甘肽治疗对非酒精性脂肪肝患者生化指标的影响

Effect of tiopronin combined with glutathione on biochemical indicators of patients with non-alcoholic fatty liver

目的观察硫普罗宁联合谷胱甘肽对非酒精性脂肪肝患者谷丙转氨酶(ALT)、谷草转氨酶(AST)、谷氨酰转移酶(GGT)、血脂和层黏蛋白(LN)水平的影响。方法选择我院从2018年3月至2019年9月收治的非酒精性脂肪肝患者84例,随机分为对照组和观察组,各42例。对照组给予硫普罗宁进行治疗,观察组在此基础上联合谷胱甘肽进行治疗。记录并比较治疗前后患者的ALT、AST、GGT、LN和血脂水平。结果经治疗,ALT、AST、GGT水平较治疗前明显下降(P<0.05),治疗后观察组ALT、AST、GGT水平低于对照组,差异有统计学意义(P<0.05);治疗前,两组血清的总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)没有统计学差异(P>0.05);治疗后观察组上述血清水平低于对照组(P<0.05),差异有统计学意义;观察组治疗后血清Ⅲ型前胶原(PCⅢ)、Ⅳ型胶原(PCⅣ)、LN水平均低于对照组,差异显著,具有统计学意义(P<0.05)。结论应用硫普罗宁联合谷胱甘肽治疗非酒精性脂肪肝,能促进肝功能的恢复,降低TC、TG、LDL的浓度,值得临床推广。

Objective To observe the effect of tiopronin combined with glutathione on the levels of alanine aminotransferase(ALT),aspartate aminotransferase(AST),glutamyltransferase(GGT),blood fat and laminin(LN)in patients with non-alcoholic fatty liver.Methods A total of 84 non-alcoholic fatty liver patients admitted to our hospital from March 2018 to September 2019 were selected and randomly divided into control group and observation group,with 42 cases in each group.The control group was treated with tiopronin,and the observation group was treated with glutathione and tiopronin.The levels of ALT,AST,GGT and blood fat were recorded and compared before and after treatment.Results After treatment,the levels of ALT,AST and GGT in the two groups were significantly lower than before treatment(P<0.05).After treatment,the levels of ALT,AST,and GGT in the observation group were different from those in the control group,which was statistically significant(P<0.05).Before treatment,there was no difference in serum TC,TG,and LDL levels between the two groups,which was not statistically significant(P>0.05).The above-mentioned serum levels of the observation group after treatment were lower than those in the control group,and there was a difference,which was statistically significant(P<0.05);the levels of PCⅢ,PCⅣ,and LN in the treatment group after treatment were significantly lower than those of the control group.The difference was statistically significant(P<0.05).Conclusion The application of tiopronin combined with glutathione in the treatment of non-alcoholic fatty liver can promote the recovery of liver function and reduce the concentrations of TC,TG and LDL,which is worthy of clinical promotion.