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Progress in mechanisms of acetylcholinesterase inhibitors and memantine for the treatment of Alzheimer’s disease

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摘要 Alzheimer’s disease(AD)is the most common causes of dementia in the elderly.Currently,only two classes of drugs,acetylcholinesterase inhibitors(AChEIs)and memantine are approved.AChEIs ameliorate cognitive and psychiatric symptoms in AD patients through activation of acetylcholine(ACh)receptors by increased synaptic ACh levels and also have protective effects against glutamate neurotoxicity and inflammation,whereas memantine appears to mainly protect against excitotoxicity and neurodegeneration.Herein,we review the pharmacologic properties of the available AChEIs and memantine,and focus on recent progress in the mechanisms of AD in relation to acetylcholinergic and glutamatergic involvement.
作者 Shao-Min Li Ming-Shu Mo Ping-Yi Xu
机构地区 Center for Neurologic Disease Department of Neurology
出处 《Neuroimmunology and Neuroinflammation》 2015年第1期274-280,共7页 神经免疫与神经炎症（英文版）
基金 the State Key Development Program for Basic Research of China(2011CB510000) the National Natural Science Foundation of China(81271428,81471292,and 81430021) a grant supported by assisting research project of science and technology for Xinjiang(201591160).
关键词 Alzheimer’s disease amyloid‑βpeptide DONEPEZIL MEMANTINE TAU
分类号 R74 [医药卫生—神经病学与精神病学]
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Neuroimmunology and Neuroinflammation
2015年 第1期

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