芪黄益肾汤对慢性肾衰竭脾肾气虚证患者微炎症状态的干预作用

Intervention effect of Qihuang Yishen decoction on microinflammation state in patients with spleen-kidney qi deficiency syndrome of chronic renal failure

【目的】探讨芪黄益肾汤对慢性肾衰竭(,CRF)脾肾气虚证患者微炎症状态的干预作用。【方法】60例CRF患者随机分为对照组和治疗组。对照组予以常规治疗,治疗组在对照组基础上加用芪黄益肾汤治疗,观察2组临床疗效,对比治疗前后血尿素氮(BUN)、血肌酐(SCr)、胱抑素C(CysC)、C反应蛋白(CRP)、肿瘤坏死因子-α(TNF-α)及白介素6(,IL-6)水平。【结果】治疗组总有效率(86.67%)高于对照组(70.00%)(P<0.05)。治疗后,2组患者BUN、Scr、CysC、CRP、IL-6及TNF-α均较治疗前下降,且治疗组低于对照组(P<0.05)。【结论】芪黄益肾汤可改善CRF患者肾功能及临床症状,其机制可能与改善炎症状态有关。

【Objective】To explore the intervention effect of Qihuang Yishen decoction on microinflammatory state in patients with spleen-kidney qi deficiency syndrome of chronic renal failure(CRF).【Methods】Sixty CRF patients were randomly divided into control group and treatment group.The control group was treated with routine treatment,and the treatment group was treated with Qihuang Yishen decoction on the basis of the control group.The clinical efficacy of the two groups was observed,and the levels of blood urea nitrogen(BUN),serum creatinine(SCr),cystatin C(CysC),C-reactive protein(CRP),tumor necrosis factor-α(TNF-α)and interleukin 6(IL-6)before and after treatment were observed.【Results】The total effective rate of in the treatment group(86.67%)was higher than that in the control group(70.00%)(P<0.05).After treatment,BUN,Scr,CysC,CRP,IL-6 and TNF-α in 2 groups were decreased compared with those before treatment,and the treatment group was lower than the control group(P<0.05).【Conclusion】Qihuang Yishen decoction can improve renal function and clinical symptoms of CRF patients,and its mechanism may be related to the improvement of inflammatory state.