小剂量氨磺必利治疗难治性抑郁症的临床效果

Effects of Low Dose Amisulpride in the Treatment of Refractory Depression

目的观察小剂量氨磺必利治疗难治性抑郁症的临床效果。方法选择2019年1月至2020年12月郑州市第八人民医院收治的68例难治性抑郁症患者作为对象,根据随机数表法分为对照组和观察组。对照组34例,接受艾司西酞普兰治疗;观察组34例,在对照组基础上联合小剂量氨磺必利治疗。治疗8周末,比较两组的药物不良反应、焦虑抑郁评分、治疗有效率等。结果观察组总有效率(74.19%)高于对照组(53.33%),差异有统计学意义(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。治疗8周后,观察组的汉密尔顿抑郁量表(HAMD)、汉密尔顿焦虑量表(HAMA)评分均低于对照组,差异有统计学意义(P<0.05)。结论使用艾司西酞普兰联合小剂量氨磺必利治疗难治性抑郁症可改善患者抑郁症状,提高治疗总有效率,且不会增加药物不良反应,安全性较好。

Objective To observe the clinical effects of low dose amisulpride in the treatment of refractory depression.Methods A total of 68 patients with refractory depression who were treated in Zhengzhou Eighth People’s Hospital from January 2019 to December 2020 were selected,and they were randomly divided into control group and observation group,with 34 cases in each group.The control group accepted escitalopram,the observation group accepted small dose of amisulpride on the basis of the control group.After 8 weeks’treatment,the adverse drug reactions,anxiety and depression scores,and treatment efficiency of the two groups were compared.Results The total effective rate of the observation group was higher than that of the control group(P<0.05),but there was no significant difference in the adverse reactions such as nausea and vomiting,insomnia and dreaminess between the two groups(P>0.05).After 8 weeks’treatment,the scores of Hamilton depression scale(HAMD)and Hamilton anxiety scale(HAMA)of the observation group were lower than those of the control group(P<0.05).Conclusion Low dose amisulpride combined with escitalopram can effectively relieve the depressive symptoms of patients with refractory depression,increase the total effective rate,and will not increase the adverse drug reactions.It is a safe and efficient treatment method.