益气通痹汤联合美托洛尔治疗气虚痰瘀型急性心肌梗死的效果

Effect of Yiqi Tongbi Decoction Combined with Metoprolol in the Treatment of Acute Myocardial Infarction with Qi Deficiency and Phlegm Stasis Type

目的探讨益气通痹汤联合美托洛尔治疗气虚痰瘀型急性心肌梗死(AMI)的临床效果。方法选取2018年1月至2021年1月于周口市人民医院接受诊疗的106例气虚痰瘀型AMI患者为研究对象,依据随机数表法将其分为对照组(53例,美托洛尔)与观察组(53例,美托洛尔联合益气通痹汤),两组均连续治疗1个月。观察两组治疗前、治疗1个月后中医证候评分、心功能[左室舒张末径(LVEDD)、左心室射血分数(LVEF)、左房室舒张早期与舒张晚期血流峰值比(E/A)],并统计两组不良反应发生情况。结果治疗1个月后,两组中医证候评分均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);治疗1个月后,两组LVEDD小于治疗前,LVEF、E/A大于治疗前,且观察组LVEDD小于对照组,LVEF、E/A大于对照组,差异有统计学意义(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论益气通痹汤联合美托洛尔可有效减轻气虚痰瘀型AMI患者临床症状,改善心功能,且安全性高。

Objective To explore the clinical efficacy of Yiqi Tongbi Decoction combined with metoprolol in the treatment of acute myocardial infarction(AMI)of Qi deficiency and phlegm stasis type.Methods A total of 106 patients with Qi deficiency and phlegm stasis type AMI treated in Zhoukou People’s Hospital from January 2018 to January 2021 were selected as the research subjects,by a random number table method was used to divide them into control group(53 cases,metoprolol)and observation group(53 cases,metoprolol combined with Yiqi Tongbi Decoction),both groups were treated continuously for 1 month,the TCM syndrome score,cardiac function[left ventricular end diastolic diameter(LVEDD),left ventricular ejection fraction(LVEF),and the ratio of early and late diastolic blood flow(E/A)]were observed before and 1 month after treatment,and the adverse reactions of the two groups were counted.Results One month after treatment,the TCM syndrome scores of both groups were lower than those before treatment,and the observation group was lower when compared with the control group(P<0.05).After one month of treatment,LVEDD was less and LVEF and E/A were greater in both groups than those before treatment,LVEDD was lower and LVEF and E/A were higher in the observation group than those in the control group(P<0.05).There was no difference in adverse reactions between the two groups(P>0.05).Conclusion Yiqi Tongbi Decoction combined with metoprolol can effectively reduce the clinical symptoms of AMI patients with Qi deficiency and phlegm stasis type,improve their cardiac function and has high safety.