分析尼可地尔治疗不稳定型心绞痛临床效果和安全性

Analysis of the Clinical Effect and Safety of Nicorandil in the Treatment of Unstable Angina Pectoris

目的分析尼可地尔治疗不稳定型心绞痛临床效果和安全性。方法于2017年7月—2020年7月,选取在该院接受治疗的68例不稳定型心绞痛患者,按照随机信封法分为参照组、研究组,各34例。予以参照组患者常规药物治疗,予以研究组患者常规药物+尼可地尔治疗,持续治疗1个月,观察两组患者治疗效果、不良反应情况。结果研究组治疗总有效率(94.12%),显著高于参照组(70.59%),差异有统计学意义(χ^(2)=6.476,P<0.05)。治疗前,参照组、研究组患者心绞痛发作次数相近[(5.58±0.47)次/周vs(5.61±0.50)次/周],差异无统计学意义(t=0.255,P>0.05);治疗后,研究组心绞痛发作次数(0.97±0.24)次/周,少于参照组(1.89±0.34)次/周,差异有统计学意义(t=12.890,P<0.05)。研究组不良反应发生率(11.76%),与参照组的8.82%相近,差异无统计学意义(χ^(2)=0.000,P>0.05)。结论对不稳定型心绞痛患者予以尼可地尔治疗,能够提升临床治疗效果,减少心绞痛发作次数,而且不增加不良反应,安全可靠。

Objective To analyze the clinical effect and safety of nicorandil in the treatment of unstable angina pectoris.Methods From July 2017 to July 2020,68 patients with unstable angina pectoris who were treated in the hospital were selected and divided into a reference group and a study group according to the random envelope method,with 34 cases in each group.Patients in the reference group were treated with conventional medications,the patients in the study group were treated with conventional drugs and nicorandil,and the treatment was continued for 1 month.The treatment effects and adverse reactions of the two groups of patients were observed.Results The total effective rate of treatment in the study group(94.12%)was significantly higher than that of the reference group(70.59%),and the difference was statistically significant(χ^(2)=6.476,P<0.05).Before treatment,the number of episodes of angina pectoris in the reference group and the study group was similar[(5.58±0.47)times/week vs(5.61±0.50)times/week],the difference was not statistically significant(t=0.255,P>0.05);after treatment,the number of angina attacks in the study group was(0.97±0.24)times/week,which was less than the reference group(1.89±0.34)times/week,and the difference was statistically significant(t=12.890,P<0.05).The incidence of adverse reactions in the study group(11.76%)was similar to that in the reference group(8.82%),and the difference was not statistically significant(χ^(2)=0.000,P>0.05).Conclusion Nicorandil treatment for patients with unstable angina pectoris can improve the clinical treatment effect,reduce the number of angina pectoris,and does not increase adverse reactions,and is safe and reliable.