2型糖尿病患者接受小柴胡汤辨证加减治疗的效果分析

Analysis of the Effect of Dialectical Addition and Subtraction Treatment of Xiaochaihu Decoction in Type 2 Diabetic Patients

目的分析2型糖尿病(T2DM)患者接受小柴胡汤辨证加减治疗的临床疗效。方法选取该院2018年1月—2021年1月收治的60例T2DM患者作为研究对象,随机数表法分为研究组、对照组,各30例。对照组接受常规降糖治疗,研究组同时接受小柴胡汤辨证加减治疗。治疗8周,比较两组总有效率、中医症候积分、糖尿病人生存质量特异性量表(DSQL评分)、血糖指标、抑郁自评量表(SDS评分)、焦虑自评量表(SAS评分)变化情况及不良反应发生率。结果治疗后研究组总有效率为96.67%显著高于对照组的80.00%,差异有统计学意义(χ^(2)=4.043,P<0.05);研究组中医症候积分(8.1±1.2)分、SDS评分(35.6±2.7)分、SAS评分(37.8±2.7)分均低于对照组(11.2±1.8)分、(43.1±3.0)分、(44.7±2.3)分,差异有统计学意义(t=7.849、10.178、10.655,P<0.05);研究组DSQL总分(34.6±2.7)分低于对照组(44.4±5.3)分,差异有统计学意义(t=9.024,P<0.05);研究组空腹血糖(6.1±1.1)mmol/L、糖化血红蛋白(6.0±1.1)%、餐后2 h血糖(8.1±1.4)mmol/L均低于对照组(7.3±1.0)mmol/L、(7.3±1.5)%、(9.3±1.5)mmol/L,差异有统计学意义(t=4.421、3.828、3.203,P<0.05);研究组不良反应发生率为3.33%低于对照组的20.00%,差异有统计学意义(χ^(2)=4.043,P<0.05)。结论T2DM患者接受小柴胡汤辨证加减治疗可有效降低中医症状积分,缓解负面情绪,降低血糖水平。

Objective To analyze the clinical efficacy of type 2 diabetes(T2 DM)patients receiving Xiaochaihu Decoction dialectical treatment.Methods A total of 60 T2 DM patients admitted to the hospital from January 2018 to January 2021 were selected as the research objects.They were divided into the study group and the control group by a random number table,with 30 cases in each group.The control group received conventional hypoglycemic therapy,and the study group also received dialectical addition and subtraction treatment of Xiaochaihu Decoction.After treatment for 8 weeks,compare the two groups’total effective rate,TCM symptom score,Diabetic Quality of Life Specific Scale(DSQL score),blood glucose index,Depression Self-Rating Scale(SDS Score),and Anxiety Self-Rating Scale(SAS Score)changes and incidence of adverse reactions.Results After treatment,the total effective rate of the study group(96.67%)was significantly higher than that of the control group(80.00%),the difference was statistically significant(χ^(2)=4.043,P<0.05);TCM syndrome score(8.1±1.2)points,SDS score(35.6±2.7)points,SAS score(37.8±2.7)points in the study group were lower than those in the control group(11.2±1.8)points,(43.1±3.0)points,(44.7±2.3)points,the difference was statistically significant(t=7.849,10.178,10.655,P<0.05);the total score of DSQL in the study group(34.6±2.7)points was significantly lower than that in the control group(44.4±5.3)points,the difference was statistically significant(t=9.024,P<0.05).the fasting blood glucose(6.1±1.1)mmol/L,h BA1 C(6.0±1.1)%and 2 h postprandial blood glucose(8.1±1.4)mmol/L in the study group were lower than those in the control group(7.3±1.0)mmol/L,(7.3±1.5)%and(9.3±1.5)mmol/L,the difference was statistically significant(t=4.421,3.828,3.203,P<0.05).the incidence of adverse reactions in study group(3.33%)was lower than that in control group(20.00%),the difference was statistically significant(χ2=4.043,P<0.05).Conclusions T2 DM patients receiving Xiaochaihu Decoction dialectical treatment can effectively reduce TCM symptom scores,relieve negative emotions,and lower blood glucose levels.