泮托拉唑联合奥曲肽治疗消化性溃疡并上消化道出血患者的效果观察

Effect of Pantoprazole Combined with Octreotide in the Treatment of Peptic Ulcer with Upper Gastrointestinal Bleeding

目的分析对消化性溃疡并上消化道出血患者应用泮托拉唑联合奥曲肽治疗的临床疗效。方法 2018年1月至2019年11月期间,在我院接受治疗的消化性溃疡并上消化道出血患者共计100例,以随机分配为依据将其均分为对照组和试验组,两组均接受泮托拉唑药,试验组再给予奥曲肽用药,治疗结束后,对比治疗效果。结果治疗后,对照组与试验组患者的总有效率分别为80.00%、98.00%,差异具有统计学意义(P<0.05);试验组患者的IL-17(170.32±7.88)pg/mL、IL-6(33.30±1.54)pg/mL显著低于对照组患者的IL-17(183.23±8.54)pg/mL、IL-6(38.01±1.98),差异具有统计学意义(P<0.05);试验组患者的IL-2(3.69±0.39)ng/mL显著高于对照组患者的IL-2(2.90±0.35)ng/mL值更高,差异具有统计学意义(P<0.05);试验组患者的Fib(2.12±0.25)g/L、APTT(22.48±1.88)s、TT(12.81±0.87)s以及PT(9.38±0.45)s显著低于对照组患者的Fib(2.90±0.28)g/L、APTT(27.01±2.10)s、TT(15.71±1.05)s以及PT(11.51±0.90)s,差异具有统计学意义(P<0.05);两组不良反应无显著差异(P>0.05)。结论对消化性溃疡并上消化道出血患者应用泮托拉唑联合奥曲肽治疗可有效减轻炎性反应,临床效果显著。

Objective To analyze the clinical efficacy of pantoprazole combined with octreotide in the treatment of peptic ulcer with upper gastrointestinal bleeding.Methods From January 2018 to November 2019,100 patients with peptic ulcer complicated with upper gastrointestinal bleeding were randomly divided into control group and experimental group.Both groups received pantoprazole,and the experimental group was given octreotide.After treatment,the clinical treatment efficiency of the two groups was compared.Results After treatment,the total effective rates of the control group and the experimental group were 80.00% and 98.00%,respectively,with statistical significance (P<0.05);the levels of IL-17 (170.32±7.88) pg/mL and IL-6 (33.30±1.54) pg/mL in the experimental group were significantly lower than those in the control group (183.23±8.54) pg/mL and IL-6 (38.01±1.98),with statistical significance (P<0.05).The level of IL-2 in the experimental group (3.69±0.39) ng/mL was significantly higher than that in the control group (2.90±0.35) ng/mL,and the difference was statistically significant (P<0.05);the FIB (2.12±0.25) g/L,APTT (22.48±1.88) s,TT (12.81±0.87) s and PT (9.38±0.45) s in the experimental group were significantly lower than those in the control group (2.90±0.28) g/L,APTT (27.01±2.10) s,TT (15.71±1.05) s,and PT (11.51±0.90) s.The difference was statistically significant (P<0.05);there was no significant difference in adverse reactions between the two groups (P>0.05).Conclusion Pantoprazole combined with octreotide in the treatment of peptic ulcer with upper gastrointestinal bleeding can effectively reduce the inflammatory reaction,and the clinical effect is significant.