介入治疗早期干预下肢深静脉血栓形成的近远期疗效分析

Analysis of Short-term and Long-term Effects of Interventional Therapy on Early Intervention of Deep Vein Thrombosis of Lower Extremities

目的研究介入治疗早期干预下肢深静脉血栓形成对近远期疗效的影响。方法将2017年2月-2019年1月该院收治的94例下肢深静脉血栓形成患者依据早期治疗方案分为两组,其中对照组早期予以低分子肝素钙进行抗凝治疗,其后采用华法林治疗,研究组则予以药物抗凝治疗同时结合介入治疗,两组均至少进行12~24个月的随访,对比近远期疗效。结果研究组膝上、膝下患侧与健侧肢体周径差分别为(1.07±0.24)、(0.95±0.18)cm,较对照组的(2.19±0.43)、(1.94±0.32)cm更优,差异有统计学意义(t=15.592、18.485,P<0.001);研究组总有效率为95.74%,高于对照组76.60%的总有效率,差异有统计学意义(χ^(2)=7.230,P=0.007);研究组随访期间有1例发生下肢深静脉血栓形成后综合征,发生率为2.13%,对照组有8例,发生率为17.02%,差异有统计学意义(χ^(2)=4.424,P=0.035)。结论下肢深静脉血栓形成采取介入治疗早期干预,有助于减轻下肢疼痛、水肿等症状,降低下肢深静脉血栓形成后综合征的发生率,获得了良好的近远期疗效。

Objective To study the effect of early intervention of interventional therapy in the treatment of deep vein thrombosis of lower extremities on the short-and long-term curative effect.Methods Ninety-four patients with deep vein thrombosis of the lower extremities admitted to the hospital from February 2017 to January 2019 were divided into two groups according to different early treatment plans.The control group was given low-molecular-weight heparin calcium for anticoagulation treatment in the early stage,followed by warfarin therapy,and the study group was given drug anticoagulation therapy combined with interventional therapy.Both groups were followed up for at least 12-24 months.Contrast short-term and long-term efficacy.Results The limb circumference difference between the affected side and the healthy side in the study group was(1.07±0.24)cm and(0.95±0.18)cm,respectively,which were better than those in the control group(2.19±0.43)cm and(1.94±0.32)cm,the difference was statistically significant(t=15.592,18.485,P<0.001);the total effective rate of the study group was 95.74%,which was higher than the control group 76.60%,the difference was statistically significant(χ^(2)=7.230,P=0.007);during the follow-up period of the study group,there was 1 case of lower extremity deep vein thrombosis syndrome,the incidence rate was 2.13%,and the control group had 8 cases,the incidence rate was 17.02%,the difference was statistically significant(χ^(2)=4.424,P=0.035).Conclusion Early intervention of interventional therapy for deep vein thrombosis of the lower extremities can help reduce the symptoms of lower extremity pain and edema,reduce the incidence of post-deep vein thrombosis syndrome,and obtain good short-term and long-term curative effects.