曼月乐与地屈孕酮片在围绝经期异常子宫出血治疗中的疗效分析

Analysis of the Curative Effect of Mirena and Dydrogesterone Tablets in the Treatment of Perimenopausal Abnormal Uterine Bleeding

目的观察围绝经期异常子宫出血患者接受曼月乐与地屈孕酮片治疗的临床疗效差异。方法随机选取2018年1月-2019年12月该院门诊治疗的围绝经期异常子宫出血患者80例实施分组,接受地屈孕酮片治疗患者为对照组(40例),接受曼月乐治疗患者为观察组(40例),对比患者治疗前后子宫内膜厚度、血红蛋白水平差异;比较患者性激素雌二醇,卵泡刺激素,黄体生成素指标差异。结果观察组经治疗,患者子宫内膜厚度(3.72±0.41)mm、血红蛋白水平(110.96±10.38)g/L,与对照组相比,差异有统计学意义(t=16.052、7.374,P<0.05)。观察组经治疗,患者雌二醇(227.36±25.67)pmol/L、黄体生成素(9.72±1.03)U/L、卵泡刺激素(9.92±0.09)U/L,与对照组相比,差异有统计学意义(t=11.466、2.718、13.519,P<0.05)。结论围绝经期异常子宫出血患者给予曼月乐较地屈孕酮片相比,对患者血红蛋白水平、子宫内膜厚度及性激素水平改善更为明显,临床应用价值更高。

Objective To observe the difference in clinical efficacy between Mirena and Dydrogesterone tablets in patients with abnormal uterine bleeding during perimenopausal period.Methods In this paper,80 patients with abnormal uterine bleeding during the perimenopausal period who were treated by the hospital from January 2018 to December 2019 were randomly selected for implementation.The patients who received dydrogesterone tablets were used as the control group(40 cases).The patients treated with Mirena were the observation group(40 cases).The differences in endometrial thickness and hemoglobin levels before and after treatment were compared;the differences in sex hormones estradiol,follicle stimulating hormone,and luteinizing hormone were compared.Results After treatment in the observation group,the endometrial thickness(3.72±0.41)mm and hemoglobin level(110.96±10.38)g/L of the patients in the observation group were different from those in the control group(t=16.052,7.374,P<0.05).After treatment in the observation group,the patient’s estradiol(227.36±25.67)pmol/L,luteinizing hormone(9.72±1.03)U/L,and follicle stimulating hormone(9.92±0.09)U/L,were significantly different from those in the control group(t=11.466,2.718,13.519,P<0.05).Conclusion Compared with dydrogesterone tablets in patients with perimenopausal abnormal uterine bleeding,Mirena can improve the hemoglobin level,endometrial thickness and sex hormone levels more significantly,and has higher clinical application value.