160例高级别脑胶质细胞瘤术后低分割同期推量调强放疗的安全性及有效性

The Safety and Effectiveness of Intraoperative Hypofractionation and Simultaneous Intensity-modulated Radiotherapy in 160 Cases of High-grade Glioma

目的探索高级别脑胶质细胞瘤患者术后采用低分割同期推量调强放疗的安全性及有效性。方法方便选取2018年2月—2020年2月该院收治的160例高级别脑胶质细胞瘤患者为研究对象,根据单双号随机化分两组,观察组和对照组各80例,对照组采用常规放疗,观察组采用低分割同期推量调强放疗,均进行2个疗程治疗,并对比两组治疗后总缓解率、不良反应发生率、平均生存时间,同时进行随访,统计3个月、6个月的生存率。结果观察组总缓解率为53.75%高于对照组的37.50%,差异有统计学意义(χ^(2)=4.258,P<0.05);不良反应发生率为2.50%低于对照组11.25%,差异有统计学意义(χ^(2)=4.783,P<0.05);观察组随访后3个月生存率为98.75%、随访后6个月生存率为88.75%,均高于对照组的87.50%、76.25%,差异有统计学意义(χ^(2)=7.907、4.329,P<0.05);观察组平均生存时间(6.84±2.24)个月长于对照组的(5.12±1.85)个月,差异有统计学意义(t=5.295,P<0.001)。结论低分割同期推量调强放疗运用于高级别脑胶质细胞瘤患者中效果显著,可提高安全性,延长生存时间,保证近期、远期疗效。

Objective To explore the safety and effectiveness of postoperative hypofractionation and concurrent intensity-modulated radiotherapy for patients with high-grade glioma.Methods Convenience selection a total of 160 patients with high-grade glioma who were admitted to the hospital from February 2018 to February 2020 as the research objects.According to the odd and even numbers,they were randomized into two groups,80 cases in each of the observation group and the control group,and the control group adopted conventional radiotherapy.The observation group was treated with hypofractionated intensity-modulated radiotherapy at the same time.Both treatments were carried out for 2 courses.The total remission rate,the incidence of adverse reactions,and the average survival time after treatment were compared between the two groups.Follow-up was performed at the same time,and the survival rates of 3 months and 6 months were counted.Results The total remission rate of the observation group was 53.75%higher than that of the control group 37.50%,the difference was statistically significant(χ^(2)=4.258,P<0.05);the adverse reaction rate was 2.50%lower than the control group 11.25%,the difference was statistically significant(χ^(2)=4.783,P<0.05);the 3-month survival rate of the observation group was 98.75%after the follow-up,and the 6-month survival rate was 88.75%after the follow-up,both higher than the 87.50%and 76.25%of the control group.The difference was statistically significant(χ^(2)=7.907,4.329,P<0.05);the average survival time of the observation group was(6.84±2.24)months longer than that of the control group(5.12±1.85)months,the difference was statistically significant(t=5.295,P<0.001).Conclusion Hypofractionation and simultaneous intensity-modulated radiotherapy has a significant effect in high-grade glioma patients,which can improve safety,prolong survival,and ensure short-term and long-term curative effects.