前列地尔联合低分子肝素钙治疗高脂血症性胰腺炎疗效分析

Therapeutic Effect of Alprostadil Combined with Low Molecular Weight Heparin Calcium in the Treatment of Hyperlipidemia Pancreatitis

目的探讨分析前列地尔联合低分子肝素钙治疗高脂血症性胰腺炎的疗效。方法于2019年1—12月在该院收治的高脂血症性胰腺炎患者中方便选取100例,随机分两组,观察组(50例)采用前列地尔联合低分子肝素钙治疗,对照组(50例)采用单纯前列地尔治疗,观察比较两组的临床疗效、症状恢复时间和禁食时间、治疗前后的CT评分和TG水平。结果观察组的临床总有效率(94.00%)显著高于对照组(80.00%),差异有统计学意义(χ^(2)=4.332,P<0.05)。观察组胰腺炎症状改善时间、血清淀粉酶恢复正常时间、禁食时间显著短于对照组,差异有统计学意义(P<0.05)。治疗后观察组的CT评分(2.16±0.39)分显著低于对照组(3.37±0.44)分,差异有统计学意义(t=14.552,P<0.05)观察组,TG水平(1.46±0.37)mmol/L显著低于对照组(3.41±0.40)mmol/L,差异有统计学意义(t=25.305,P<0.05)。结论在高脂血症性胰腺炎的治疗中采用前列地尔联合低分子肝素钙的疗效显著,预后更佳。

Objective To explore and analyze the efficacy of alprostadil combined with low molecular weight heparin calcium in the treatment of hyperlipidemia pancreatitis.Methods A total of 100 patients with hyperlipidemia pancreatitis admitted to the hospital from January to December 2019 were Conveniently selected and randomly divided into two groups.The observation group(50 cases)was treated with alprostadil combined with low-molecular-weight heparin calcium,and the control group(50 cases)were treated with alprostadil alone,and the clinical efficacy,symptom recovery time and fasting time,CT score and TG level before and after treatment were observed and compared between the two groups.Results The total clinical effective rate of the observation group(94.00%)was significantly higher than that in the control group(80.00%),and the difference was statistically significant(χ^(2)=4.332,P<0.05).The time for improvement of pancreatitis symptoms,the time for serum amylase to return to normal,and the fasting time of the observation group were significantly shorter than those of the control group,the difference was statistically significant(P<0.05).After treatment,the CT scores of the two groups were compared to the observation group(2.16±0.39)points,was significantly lower than the control group(3.37±0.44)points,the difference was statistically significant(t=14.552,P<0.05).The TG level of the observation group(1.46±0.37)mmol/L was significantly lower than the control group(3.41±0.40)mmol/L,the difference was statistically significant(t=25.305,P<0.05).Conclusion The use of alprostadil combined with low molecular weight heparin calcium in the treatment of hyperlipidemia pancreatitis has a significant effect and a better prognosis.