多相支架在牙周再生领域的研究进展

Research progress on multiphasic scaffold in periodontal regeneration

牙周炎导致的牙周组织破坏会引起牙齿松动及脱落,危害口腔甚至全身健康。近年来牙周各组织的时空关系及其功能重建已经成为研究前沿,这对传统的牙周组织再生相关技术提出了更高的要求。多相支架作为一种新兴组织工程材料,其区域特异性在重建软硬组织生理特性和功能关系方面均表现出独特的优势,成为牙周再生以及功能整合的关键。本文对近年来多相支架在牙周结构及功能再生领域的研究进展进行综述,关注其与生长因子传递、干细胞技术、现有牙周治疗策略以及新兴材料技术相结合的前沿,进一步指导未来组织工程与口腔医学领域的合作方向。

Periodontal tissue damage caused by periodontitis can lead to the mobility and loss of tooth, thereby endangering oral health and even general health. The temporal and spatial relationship of periodontal tissues and their functional reconstruction have become a research frontier, which sets higher demands on traditional therapeutic techniques. As a new type of tissue-engineered materials, multiphasic scaffolds show unique advantages in rebuilding the physiological characteristics and functional relationships of soft and hard tissues, which are keys to periodontal regeneration and functional integration. This article reviews the research progress on multiphase scaffolds in the field of periodontal structure and functional regeneration. It focuses on the frontier of the combination of these scaffolds with growth factor delivery, stem cell technology, existing periodontal treatment strategies, and emerging material technologies. This study serves as a guide for the future integration of tissue engineering and stomatology.