摘要
目的探讨纤维蛋白原与淋巴细胞比值(FLR)所建立的新型预测模型在评价老年食鳞癌病人放疗近期疗效和预后的价值。方法收集2014年1月至2018年1月徐州医科大学附属医院放射治疗科接受放射治疗并符合入组条件的老年食管癌127例资料。根据受试者ROC曲线求得纤维蛋白原与淋巴细胞比值对的最佳截断值,并以此计算FLR水平与食管鳞癌临床病理特征和预后的关系。结果受试者工作特征曲线(ROC)显示,放疗前FLR的最佳截断值为2.05。根据2.05将127例病人分为低FLR(n=56例)和高FLR(n=71例)。不同FLR水平病人累积生存率经log-rank检验结果显示,FLR高水平病人共56例,生存时间为(23.87±4.05)月,FLR低水平组共71例,生存时间为(55.21±3.99)月,FLR高水平者明显低于FLR低水平者,差异有统计学意义(P<0.05)。低FLR组放疗有效率为91.0%,高FLR组有效率为71.8%,差异有统计学意义(P<0.05)。单因素分析显示,FLR、N分期、T分期、TNM分期是影响老年食管鳞癌病人总生存(Overall survival,OS)的因素,多因素分析显示,FLR、N分期是影响老年食管鳞癌病人OS的因素。结论高水平的FLR提示老年食管鳞癌病人放疗近期疗效、预后均较差。
Objective To explore the value of a new prediction model based on the ratio of fibrinogen to lymphocyte(FLR)in evaluating the short-term efficacy and prognosis of radiotherapy in elderly patients with esophagal squamous cell carcinoma.Methods From January 2014 to January 2018,127 elderly patients with esophageal cancer who received radiotherapy in the Radiotherapy Department of Affiliated Hospital of Xuzhou Medical University were collected.According to the operating characteristic curve(ROC)of the subjucts,the best cutoff value of the fibrinogen to lymphocyte ratio was obtained,and the relationship between FLR level and clinicopathological characteristics and prognosis of ESCC was calculated.Results ROC showed that the best cutoff value of FLR before radiotherapy was 2.05.According to 2.05,127 patients were divided into low FLR(n=56)and high FLR(n=71).The cumulative survival rate of patients with different FLR levels by log-rank test showed that 56 patients with high FLR had a survival time of(23.87±4.05)months,and 71 patients with low FLR had a survival time of(55.21±3.99)months.The survival time in patients with high FLR level was significantly lower than that of the low FLR level,and the difference was statistically significant(P<0.05),and the effective rate in the high FLR group was 71.8%.The difference was statistically significant(P<0.05).Single factor analysis showed that FLR,N stage,T stage and TNM stage were the factors influencing the overall survival(OS)of elderly patients with esophageal squamous cell carcinoma.Multi-factor analysis showed that FLR and N stage were the factors influencing OS in elderly patients with esophageal squamous cell carcinoma.Conclusion High level of FLR is indicative of poor short-term efficacy and prognosis of radiotherapy in the elderly patients with esophageal squamous cell carcinoma.
作者
姚若愚
展浩
鲍强
张旭光
YAO Ruoyu;ZHAN Hao;BAO Qiang;ZHANG Xuguang(Graduate School of Xuzhou Medical University,Xuzhou,Jiangsu 221004,China;Xuzhou Tumor Hospital,Xuzhou,Jiangsu 221000,China)
出处
《安徽医药》
CAS
2021年第10期1972-1976,共5页
Anhui Medical and Pharmaceutical Journal
基金
江苏省自然科学基金项目(BK20151156)。
