胶质瘤相关癌基因蛋白-1在管腔型乳腺癌组织中表达及其与预后的关系

Expression of gli1 in luminal breast cancer tissue and its relationship with prognosis

目的探讨胶质瘤相关癌基因蛋白-1(Gli1)在管腔(Luminal)型乳腺癌组织中表达及其与预后的关系。方法选取信阳市中心医院2012年7月至2014年7月收治的68例Luminal型乳腺癌病人临床资料进行回顾性分析。采用免疫组化方法检测乳腺癌组织及癌旁组织Gli1蛋白表达情况,分析Gli1蛋白表达与Luminal型乳腺癌病理特征及预后关系。结果乳腺癌组织Gli1高表达率(45.59%)高于癌旁组织Gli1高表达率(13.33%),χ^(2)=9.433,差异有统计学意义(P<0.05);Gli1蛋白高表达与Luminal型乳腺癌淋巴结转移密切相关(P<0.05);Gli1高表达5年无复发生存率(67.74%)低于Gli1低表达5年无复发生存率(89.19%),差异有统计学意义(P<0.05);淋巴结转移、Gli1高表达是影响Luminal型乳腺癌无复发生存时间的独立危险因素(P<0.05)。结论Gli1蛋白在Luminal型乳腺癌组织中表达上调,并且与Luminal型乳腺癌复发转移密切相关。

Objective To explore expression of glioma oncogene protein-1(Gli1)in Luminal breast cancer tissue and its relationship with prognosis.Methods The clinical data of 68 patients with Luminal breast cancer who were admitted to the hospital from July 2012 to July 2014 were retrospectively analyzed.The expression of Gli1 in breast cancer tissue and para-cancerous tissue was detected by immunohistochemistry.The relationship between Gli1 expression and pathological features of Luminal breast cancer,prognosis was analyzed.Results The high expression rate of Gli1 in breast cancer tissue(45.59%)was higher than 13.33%in para-cancerous tissue(χ^(2)=9.433,P<0.05).The high expression of Gli1 was closely related to lymph node metastasis of Luminal breast cancer(P<0.05).The 5-year recurrence-free survival rate of Gli1 high expression(67.74%)was lower than 89.19%of Gli1 low expression(P<0.05).Lymph node metastasis and Gli1 high expression were independent risk factors influencing recurrence-free survival of Luminal breast cancer(P<0.05).Conclusion Gli1 is up-regulated in Luminal breast cancer tissue,which is closely related to recurrence and metastasis of Luminal breast cancer.