碳酸锂配合改良电休克治疗双相情感障碍患者的疗效及对炎症氧化因子的影响

Effect of lithium carbonate combined with modified electroconvulsive therapy on patients with bipolar disorder and their inflammatory oxidative factors

目的探究碳酸锂配合改良电休克治疗双相情感障碍(BPD)患者的临床效果及对炎症氧化因子的影响。方法选取玉林市第四人民医院2018年1月—2019年12月60例BPD患者作为研究对象,按照随机数字表法分为研究组、对照组,各30例。对照组给予碳酸锂治疗,研究组给予碳酸锂配合改良电休克治疗。治疗4周,比较2组治疗效果、碳酸锂服用剂量、治疗前后血清炎症氧化因子[白细胞介素-1β(IL-1β)、肿瘤坏死因子-α(TNF-α)、丙二醛(MDA)、超氧化物歧化酶(SOD)]水平、Bech-Rafaelsen躁狂量表(BRMS)评分及不良反应发生情况。结果研究组总有效率为93.33%(28/30),高于对照组的73.33%(22/30),碳酸锂服用剂量少于对照组,治疗4周后BRMS评分低于对照组(P<0.05)。治疗4周后2组血清SOD水平高于治疗前,IL-1β、TNF-α、血清MDA低于治疗前,研究组均优于对照组(P<0.05)。2组治疗期间不良反应发生率的差异无统计学意义(P>0.05)。结论碳酸锂配合改良电休克治疗BPD安全有效,可显著缓解患者躁狂表现,同时减轻机体炎症反应,调节抗氧化功能,碳酸锂服用剂量较少,临床效果较好。

Objective To explore the clinical effect of lithium carbonate combined with modified electroconvulsive therapy on patients with bipolar disorder(BPD)and their inflammatory oxidative factors.Methods A total of 60 BPD patients in the Fourth People's Hospital of Yulin from January 2018 to December 2019 were selected as subjects.According to the random number table method,they were randomly divided into two groups(n=30):a study group and a control group.The control group was treated with lithium carbonate,while the study group was treated with lithium carbonate combined with modified electroshock.After four weeks of treatment,both groups were compared for their therapeutic effects,dosage of lithium carbonate and the levels of serum inflammatory oxidation factor,such as interleukin-1β(IL-1β),tumor necrosis factor-α(TNF-α),malondialdehyde(MDA),and superoxide dismutase(SOD)before and after treatment.Furthermore,their Bech rafaelsen mania scale(BRMS)scores and adverse reactions were recorded.Results The total effective rate in the study group was 93.33%(28/30),which was higher than 73.33%(22/30)in the control group.The dosage of lithium carbonate was less than that in the control group.After four weeks of treatment,the BRMS score was lower than that in the control group(P<0.05).After four weeks of treatment,the levels of serum SOD in the two groups were higher than those before treatment,while IL-1β,TNF-αand serum MDA levels were lower than those before treatment,where the study group was better than the control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions Lithium carbonate combined with modified electroshock is safe and effective in the treatment of BPD.It can significantly alleviate the manic performance of patients,reduce the inflammatory reaction and regulate antioxidant function.The dosage of lithium carbonate is less,and the overall clinical effect is ideal.