1-烷氧基-4-羟基-2,2,6,6-四甲基哌啶醇的催化合成

Catalytic Synthesis of 1-Alkoxy-4-hydroxyl-2,2,6,6-tetramethylpiperidine

以4-羟基-2,2,6,6-四甲基哌啶氮氧自由基(ZJ-701)和醇为原料,铜吡啶配合物为催化剂,30%过氧化氢为氧化剂,通过氧化和O-烷基化合成了几种1-烷氧基-4-羟基-2,2,6,6-四甲基哌啶醇,通过核磁共振谱、红外光谱和质谱表征了其结构.结果表明:醇烷基对目标产物的合成有明显的影响,当碳数为3,且为直链(正丙醇)时,目标产物的产率最高,且易提纯.

Using 4-hydroxy-2,2,6,6-tetramethyl-piperidinooxy(ZJ-701)and alcohols as raw materials,30%H2O2 as oxidant and Cu complex of pyridine as catalyst,several 1-alkoxy-4-hydroxyl-2,2,6,6-tetramethylpiperidines were synthesized by oxidation and O-alkylation,and their structure were characterized by NMR,IR and MS in this paper.The results reveals that the alkyl of alcohol has an obvious effect on the synthesis of the target products,when the carbon number of alkyl is 3,and its chain is linear,the yield of the target products is highest,and the target products is easy to purification.Compared with the mothed reported in literatures,the yield is increased markedly.