摘要
Neuroimaging evidence of disconnection syndrome of Alzheimer’s disease(AD)is extremely fascinating.In the study by Brier et al.,^([1])they examined resting-state functional-connectivity magnetic resonance imaging(rs-fcMRI)in 5 functionally defined brain networks:default mode network(DMN),executive control network(CON),salience network(SAL),dorsal attention network(DAN),and sensory-motor network(SMN).Within a large sample size of human participants of either sex(n=510),they divided subjects into three subgroups according to different AD severities,i.e.unaffected(clinical dementia rating,CDR 0),very mild(CDR 0.5),and mild AD(CDR 1).
