脑肠轴在创伤性脑损伤中的作用及机制研究进展

Research progress in function and related mechanism of gut-brain axis in traumatic brain injury

创伤性脑损伤(TBI)及其并发症是目前严重影响人类健康的公共卫生问题之一,为此大量研究从不同角度深入探讨TBI的病理过程,以期发现新的治疗靶点。近年来,TBI的病理过程与脑肠轴内菌群、代谢产物、炎症因子、神经体液改变的关系受到广泛关注,不仅深入地揭示了TBI对脑肠轴的作用方式,也为进一步改善TBI救治率和恢复水平提供了新靶点。但脑肠轴精细而复杂的自我调节能力及TBI患者基础情况的异质性,极大地限制了相关研究成果的推广及临床转化。笔者就TBI对脑肠轴的影响及脑肠轴在TBI病理反应中作用的研究进展进行综述,为深入了解脑肠轴与TBI的相互关系提供一定的思路和参考。

Traumatic brain injury(TBI)in combination with its sequelae is currently a public health problem that seriously endangers human health.Accumulating studies have deeply investigated the pathological processes of TBI to find possible therapeutic targets.In recent years,the relationship between TBI pathogenesis and gut-brain axis changes in aspects of microflora,metabolites,inflammatory factors and neurohumoral changes has drawn widespread attention,which not only provides a better understanding how TBI affects gut-brain axis,but also provides new therapeutic targets in improving cure rate and recovery level after TBI.However,due to the existence of complicated gut-brain axis self-regulation as well as the individual differences of TBI patients,the recognition and transformation for the latest experimental research are largely limited.In this review,the authors summarize how TBI event influences gut-brain axis balance,as well as how gut-brain axis regulates TBI pathogenesis mutually,so as to provide a better understanding of the interaction between gut-brain axis and TBI.