常规腹腔镜手术与穿刺硬化术在肾囊肿患者中的应用及对患者免疫功能的影响

The application of routine laparoscopic operation and puncture sclerotherapy in patients with renal cyst and its effect on immune function

目的研究常规腹腔镜手术与穿刺硬化术在肾囊肿患者中的应用及对患者免疫功能的影响。方法选择本院2017年1月至2019年12月收治的143例单纯性肾褒肿患者作为研究对象,根据患者的手术意愿,分为常规腹腔镜手术患者104例,肾姨肿穿刺硬化术患者39例,比较两组患者的治疗效果、围手术期指标、不良反应以及免疫功能指标之间的差异:结果两组患者的手术时间、术中出血量以及术后住院时间比较,差异无统计学意义(P>0.05);穿刺硬化组患者的囊肿消失率显著高于腹腔镜组(P<0.05);两组患者术后发生皮下水肿、腹膜后水肿以及面部潮热情况比较,差异无统计学意义(12.82%vs.11.54%,P>0.05);经过治疗后,两组患者的CD3^(+)、CD4^(+)、CD8^(+)、CD4^(+)/CD8^(+)水平显著升高,且穿刺硬化组患者的CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)水平显著高于腹腔镜组(P<0.05)。结论穿刺硬化术在肾囊肿患者治疗中效果较好,机体免疫水平恢复较快,安全性较好,建议临床推。

Objective To study the application of routine laparoscopic operation and puncture sclerotherapy in patients witli renal cyst and the effect on immune function.Methods In this study,143 patients with simple renal cysts admitted to our hospital from January 2017 to December 2019 were selected as the research objects.According to the patients wishes,104 patients with conventional laparoscopic surgery and 39 patients with renal cyst puncture and sclerotherapy were compared between the two groups in terms of treatment effect,perioperative indicators,adverse reactions and immune function indicators.Results There was no significant difference in operation time,intraoperative hemorrhage and postoperative hospital stay between the two groups(P>0.05).The disappearance rate of cyst in puncture sclerosis group was significantly higher than that in laparoscopic group(P<0.05).After treatment,the levels of CD3^(+),CD4^(+),CD8^(+),CD4^(+)/CD8^(+) in the two groups were significantly higher,and the levels of CD3^(+),CD4^(+),CD8^(+),CD4^(+)/CD8^(+) in the puncture sclerotherapy group were significantly higher than those in the laparoscopic group(P<0.05).Conclusions Puncture sclerotherapy has a good effect in the treatment of renal cyst.The immune level of the body recovers quickly and the safety is good.It is recommended to be popularized clinically.