基于氧化[3+2]环加成反应合成二氢苯并呋喃类天然产物

Advances on the Synthesis of Natural Products with Dihydrobenzo-furan Skeleton via Oxidative[3+2]Cycloadditions

二氢苯并呋喃结构单元广泛存在于生物碱及萜类等多种天然产物中,这些天然产物大多具有良好的生物活性和药用价值.因此,近年来有关具有二氢苯并呋喃环骨架的天然产物全合成工作不断涌现.综述了近十多年来氧化[3+2]环加成反应在构建二氢苯并呋喃环骨架及各类天然产物全合成方面的应用进展.

Dihydrobenzofuran structure units widely exist in a variety of natural products,such as alkaloids and terpenes.The total synthesis of natural products containing dihydrobenzofuran skeleton has thus emerged in recent years,because of their good biological activities and medicinal value.The application progress of oxidative[3+2]cycloaddition in the construction of dihydrobenzofuran ring skeleton and the total synthesis of various natural products in recent ten years was reviewed.