过渡金属催化氮原子导向的芳基邻位C-H键硼化反应研究进展

Advances in Nitrogen-Directed Aromatic Compound ortho-C-H Bond Borylation Catalyzed by Transition Metals

芳基硼化合物在合成化学、材料化学和生物医学领域都有着广泛的应用,其合成方法一直是有机合成领域中的研究热点.导向基团辅助过渡金属催化的C-H键硼化反应具有步骤经济性,底物多样性,高区域选择性的优点.其中含氮原子导向基团底物的硼化反应引起了学者们的兴趣,因为N, C螯合的四配位有机硼化物是重要的光电材料.按照不同过渡金属(铱、铑、钯、钌)总结了近年来含氮原子导向的芳香化合物邻位C-H键硼化反应的进展.

Aromatic boron compounds have been widely used in synthetic chemistry,materials and medicinals,and developing new methods for their synthesis has been a hot topic.Directing groups assisted C—H bond borylation catalyzed by transition metal has significant advantages in step-economy,substrates diversity and high regio-selectivity.The borylation of nitrogen-based substrates has attracted interest from researchers,because four-coordinated organoboron compounds chelated by N,C are important photoelectric materials.In this paper,the preparation of aromatic boron compounds from ortho-C—H bond borylation catalyzed by Ir,Rh,Ru,Pd assisting by directing groups containing nitrogen atoms is summarized.