无配体条件钯催化内炔的氢膦酰化反应合成(E)-烯烃膦酸酯类化合物

Ligand-Free Pd-Catalyzed Hydrophosphorylation of Internal Alkynes for the Synthesis of E-Vinylphosphonates

报道了在不同醇中无配体条件下钯催化二苯基 H-亚膦酸酯对内炔的氢膦酰化反应合成E-烯烃膦酸酯类化合物的方法.这种实用且通用的三组分反应涉及二苯基 H-亚膦酸酯对相对惰性内炔的顺式加成,以及伴随的二苯基 H-亚膦酸酯的酯交换过程.反应具有高立体选择性、宽泛的底物范围和无需额外配体等显著特点.

A ligand-free Pd-catalyzed hydrophosphorylation of internal alkynes with diphenyl H-phosphonate in various alcohols for the synthesis of E-vinylphosphonates has been reported.This pratical and versatile three-component reaction involves the syn-addition of diphenyl H-phosphonate towards relatively inactive internal alkynes,as well as the concomitant transesterification of diphenyl H-phosphonate.The remarkable features include high stereoselectivity,wide substrate scope and the absence of additional ligands.