肝硬化患者临床凝血功能检验中全自动血凝仪测定的应用及临床价值研究

Study on the application and clinical value of automatic blood coagulation apparatus in clinical coagulation function test of patients with cirrhosis

目的探讨肝硬化患者临床凝血功能检验中全自动血凝仪测定的应用及临床价值。方法选取2018年1月—2020年1月我院收治的64例肝硬化患者(肝硬化组),并纳入同期来我院接受健康体检者64例(对照组),应用全自动血凝仪对肝硬化患者临床凝血指标检测。再将肝硬化组患者分为出血组与无出血组,比较对照组与肝硬化组、出血与无出血组、不同肝功能分级患者血小板参数与PT检测结果。结果与对照组比较,肝硬化组PDW、PT、MPV、INR水平更高,PCT、PLT水平更低(P<0.05);与肝硬化无出血组比较,肝硬化出血组PDW、PT、MPV、INR水平更高,PCT、PLT水平更低(P<0.05);与Child-Pugh A级患者比较,肝硬化Child-Pugh B级与C级患者PDW、PT、MPV、INR水平更高,PCT、PLT水平更低(P<0.05)。结论在肝硬化患者病情评价中凝血功能检验发挥重要作用,可为患者临床治疗提供有效理论依据,诊断准确率较高,有利于临床治疗措施制定。因此,凝血功能检验应在肝硬化疾病诊断中广泛应用。

Objective To explore the application and clinical value of automatic blood coagulation apparatus in clinical coagulation function test of patients with cirrhosis.Methods A total of 64 patients with cirrhosis admitted to our hospital from January 2018 to January 2020(cirrhosis group)were selected,and 64 healthy subjects admitted to our hospital during the same period(control group)were included.The clinical coagulation indexes of patients with cirrhosis were detected by automatic blood coagulation apparatus.Patients in cirrhosis group were divided into bleeding group and non-bleeding group;platelet parameters and PT test results were compared between control group and cirrhosis group,bleeding group and non-bleeding group,and patients with different liver function grades.Results Compared with the control group,the levels of PDW,PT,MPV and INR in cirrhosis group were higher,and the levels of PCT and PLT were lower(P<0.05).Compared with liver cirrhosis non-bleeding group,the levels of PDW,PT,MPV and INR were higher in liver cirrhosis with bleeding group,and the levels of PCT and PLT were lower(P<0.05).Compared with Child-Pugh A patients,the levels of PDW,PT,MPV and INR in Child-Pugh B and C patients with cirrhosis were higher,and the levels of PCT and PLT were lower(P<0.05).Conclusion The test of coagulation function plays an important role in the evaluation of patients with cirrhosis,and can provide effective theoretical basis for the clinical treatment of patients with high diagnostic accuracy,which is conducive to the formulation of clinical treatment measures.Therefore,the test of coagulation function should be widely used in the diagnosis of cirrhosis.