氨溴索联合甲泼尼龙对哮喘急性发作症状缓解及肺功能的影响

Effects of ambroxol combined with methylprednisolone on symptom relief and pulmonary function in patients with acute asthma attack

目的探讨氨溴索联合甲泼尼龙对哮喘急性发作症状缓解及肺功能的影响。方法选取2016年5月~2019年5月山东省枣庄市肿瘤医院收治的100例急性哮喘患者,依据随机数表法分为两组,各50例,两组均予以常规止咳平喘等综合治疗,对照组在此基础上加用注射用甲泼尼龙琥珀酸钠注射治疗,观察组在对照组基础上加用盐酸氨溴索注射液静脉滴注治疗。对比两组治疗前、治疗1周后症状缓解情况和肺功能指标。肺功能指标包括第一秒用力呼气量(FEV1)、用力肺活量(FVC)及一秒率(FEV1/FVC)。结果治疗1周后,观察组患者有效率明显高于对照组,两组患者FEV1、FVC及FEV1/FVC水平升高,且观察组患者改善幅度大于对照组(P<0.05)。结论氨溴索联合甲泼尼龙治疗急性发作哮喘患者效果明显,可有效缓解症状,改善肺功能指标,值得临床应用。

Objective To investigate the effect of ambroxol combined with methylprednisolone on symptom relief and lung function in patients with acute asthma attack.Methods 100 patients from Zaozhuang Cancer Hospital with acute asthma from May 2016 to May 2019 were divided into two groups according to the table of random numbers,50 cases in each group.Control group was treated with methylprednisolone sodium succinate injection and the observation group was treated with ambroxol hydrochloride injection.Before treatment and 1 week after treatment,symptom relief and pulmonary function indices were compared between the two groups.Pulmonary function indices include the first second forced respiratory volume(FEV1),forced vital capacity(FVC)and the ratio of the first second forced expiratory volume to all expiratory volumes(FEV1/FVC).Results After 1 week of treatment,the effective rate of the patients in the observation group was significantly higher than that in the control group.The levels of FEV1,FVC and FEV1/FVC in the two groups were increased,and the improvement extent of the patients in the observation group was significantly higher than that in the control group(P<0.05).Conclusion Ambroxol combined with methylprednisolone in the treatment of acute attack of asthma is effective,and can effectively relieve symptoms,improve pulmonary function indicators,being worthy of clinical promotion.