依沙吖啶联合米非司酮和米索前列醇在中期妊娠引产中的应用效果观察

Observation on the practical effect of ethacridine combined with mifepristone and misoprostol in the treatment of induced labor in the second trimester of pregnancy

目的观察依沙吖啶联合米非司酮和米索前列醇在中期妊娠引产中的应用效果。方法60例中期妊娠引产孕妇,根据随机数字分表法分为观察组和参照组,各30例。参照组应用单一依沙吖啶引产,观察组应用依沙吖啶联合米非司酮和米索前列醇引产。比较两组临床指标(用药至宫缩时间、引产时间、引产后2 h出血量、引产后出血时间)、引产情况及不良事件发生情况。结果观察组用药至宫缩时间(17.42±3.95)h、引产时间(6.51±4.24)h及引产后出血时间(9.60±3.21)d均短于参照组的(42.46±8.81)h、(16.20±6.05)h、(12.47±5.58)d,引产后2 h出血量(87.35±42.14)ml少于参照组的(126.71±77.30)ml,差异具有统计学意义(P<0.05)。观察组引产成功率96.67%高于参照组的70.00%,差异具有统计学意义(P<0.05)。观察组不良事件发生率低于参照组,差异具有统计学意义(P<0.05)。结论对中期妊娠引产孕妇应用依沙吖啶联合米非司酮和米索前列醇效果明显优于单一依沙吖啶,其能够缩短引产时间、减少出血量,同时可提高引产率,且不良反应少,安全性较高,具有应用价值。

Objective To observe the practical effect of ethacridine combined with mifepristone and misoprostol in the treatment of induced labor in the second trimester of pregnancy.Methods A total of 60 patients with inducted labor during the second trimester of pregnancy were divided into observation group and reference group according to random numerical table,with 30 cases in each group.The reference group received ethacridine alone for labor induction,and the observation group received ethacridine,mifepristone and misoprostol for labor induction.The clinical indicators(time from medication to uterine contraction,labor induction time,hemorrhage at 2 h after labor induction,hemorrhage time after labor induction),labor induction and occurrence of adverse events were compared between the two groups.Results The time from medication to uterine contraction(17.42±3.95)h,labor induction time(6.51±4.24)h and hemorrhage time after labor induction(9.60±3.21)d in the observation group were shorter than(42.46±8.81)h,(16.20±6.05)h and(12.47±5.58)d in the reference group,and the hemorrhage at 2 h after labor induction(87.35±42.14)ml was less than(126.71±77.30)ml in the reference group.All the difference was statistically significant(P<0.05).The success rate of labor induction was 96.67%in the observation group,which was higher than 70.00%in the reference group,and the difference was statistically significant(P<0.05).The incidence of adverse events in the observation group was lower than that in the reference group,and the difference was statistically significant(P<0.05).Conclusion Compared with ethacridine alone,the combination of ethacridine,mifepristone and misoprostol has obviously better effect in the treatment of the patients with induced labor in the second trimester of pregnancy,and it can shorten the labor induction time,reduce blood loss,and at the same time increase the labor induction rate,with fewer adverse reactions and higher safety.This method contains practical value.