耳后与鼓室注射甲泼尼龙琥珀酸钠治疗突发性耳聋的效果

Effect of post-auricular and tympanic injection of methylprednisolone sodium succinate on sudden deafness

目的分析耳后与鼓室注射甲泼尼龙琥珀酸钠治疗突发性耳聋的效果。方法88例突发性耳聋患者,按随机数字表法分为鼓室给药组和耳后给药组,每组44例。鼓室给药组患者给予鼓室注射甲泼尼龙琥珀酸钠治疗,耳后给药组给予耳后注射甲泼尼龙琥珀酸钠。比较两组患者治疗前后纯音听阈测定水平及治疗效果、不良反应发生情况。结果治疗前,两组500、1000、2000 Hz纯音听阈测定水平比较,差异无统计学意义(P>0.05);治疗后,两组500、1000、2000 Hz纯音听阈测定水平均优于治疗前,且耳后给药组500、1000、2000 Hz纯音听阈测定水平分别为(35.56±5.21)、(37.56±2.21)、(39.19±5.44)dB,优于鼓室给药组的(52.34±8.26)、(55.56±5.67)、(58.21±8.67)dB,差异有统计学意义(P<0.05)。耳后给药组总有效率100.00%高于鼓室给药组的77.27%,差异有统计学意义(P<0.05)。耳后给药组不良反应发生率低于鼓室给药组,差异有统计学意义(P<0.05)。结论耳后注射甲泼尼龙琥珀酸钠治疗突发性耳聋的效果更好,且安全性更高,值得推广。

Objective To analyze the effect of post-auricular and tympanic injection of methylprednisolone sodium succinate on sudden deafness.Methods A total of 88 patients with sudden deafness were randomly divided into tympanic administration group and post-auricular administration group,with 44 cases in each group.Patients in the tympanic administration group were treated with intratympanic injection of methylprednisolone sodium succinate,while patients in the post-auricular administration group were treated with post-auricular injection of methylprednisolone sodium succinate.Both groups of patients were compared in terms of pure tone audiometry before and after treatment,therapeutic effect and occurrence of adverse reactions.Results Before treatment,there was no statistically significant difference in the levels of pure tone audiometry at 500,1000 and 2000 Hz between the two groups(P>0.05).After treatment,the pure tone audiometry of the two groups at 500,1000,and 2000 Hz were better than those before treatment,and the pure tone audiometry of post-auricular administration group at 500,1000,and 2000 Hz were(35.56±5.21)and(37.56±2.21),(39.19±5.44)dB respectively,which were better than(52.34±8.26),(55.56±5.67),(58.21±8.67)dB of tympanic administration group.All the differences were statistically significant(P<0.05).The total effective rate 100.00%of post-auricular administration group was higher than 77.27%of the tympanic administration group,and the difference was statistically significant(P<0.05).The incidence of adverse reactions in the post-auricular administration group was lower than that in the tympanic administration group,and the difference was statistically significant(P<0.05).Conclusion Post-auricular injection of methylprednisolone sodium succinate has good effect and high safety on sudden deafness,and it is worthy of promotion.