改良根除术联合自体植皮术治疗乳腺癌的效果观察

Effect observation of modified radical mastectomy combined with autologous skin grafting in the treatment of breast cancer

目的研究改良根除术联合自体植皮术治疗乳腺癌的效果。方法100例乳腺癌患者,应用计算机随机排序的方式分为对照组和研究组,每组50例。对照组患者行改良根除术治疗,研究组患者行改良根除术联合自体植皮术治疗。对比两组患者手术情况,皮瓣坏死与淋巴水肿发生情况,二次植皮率。结果研究组患者手术时间、术中出血量、引流时间以及住院时间分别为(105.6±14.6)min、(202.8±19.3)ml、(8.9±2.2)d、(15.0±3.1)d,对照组患者手术时间、术中出血量、引流时间以及住院时间分别为(92.4±11.3)min、(182.3±15.8)ml、(9.1±2.0)d、(10.8±2.7)d;两组患者引流时间比较差异无统计学意义(t=0.476,P=0.635>0.05),研究组手术时间、住院时间均长于对照组,术中出血量大于对照组,差异有统计学意义(t=5.056、7.224、5.812,P=0.000、0.000、0.000<0.05)。研究组患者皮瓣坏死与淋巴水肿发生率分别为8.00%、4.00%,均明显低于对照组的30.00%、24.00%,差异有统计学意义(χ^(2)=7.862,8.306;P=0.005,0.004P<0.05)。研究组患者二次植皮率2.00%低于对照组的18.00%,差异有统计学意义(χ^(2)=7.111,P=0.008<0.05)。结论将改良根除术联合自体植皮术应用于乳腺癌患者治疗中能取得较好的临床疗效。

Objective To study the effect of modified radical mastectomy combined with autologous skin grafting in the treatment of breast cancer.Methods A total of 100 patients with breast cancer were divided into control group and research group according to computerized random method,with 50 cases in each group.The control group was treated with modified radical mastectomy,and the research group was treated with modified radical mastectomy and autologous skin grafting.Patients in both groups were compared in terms of surgical status,occurrence of flap necrosis and lymphedema,and the rate of secondary skin grafting.Results The operation time,intraoperative blood loss,drainage time and hospitalization time in the research group were(105.6±14.6)min,(202.8±19.3)ml,(8.9±2.2)d and(15.0±3.1)d,respectively;the operation time,intraoperative blood loss,drainage time and hospitalization time of the control group were(92.4±11.3)min,(182.3±15.8)ml,(9.1±2.0)d and(10.8±2.7)d,respectively.The difference in drainage time between the two groups was not statistically significant(t=0.476,P=0.635>0.05).The operation time and hospitalization time in the research group were longer than those in the control group,and the intraoperative blood loss was greater than that in the control group.All the difference was statistically significant(t=5.056,7.224,5.812;P=0.000,0.000,0.000<0.05).The incidences of skin flap necrosis and lymphedema in the research group were 8.00%and 4.00%,respectively,which were significantly lower than 30.00%and 24.00%in the control group,and the difference was statistically significant(χ^(2)=7.862,8.306;P=0.005,0.004<0.05).The rate of secondary skin grafting 2.00%in the research group was lower than 18.00%in the control group,and the difference was statistically significant(χ^(2)=7.111,P=0.008<0.05).Conclusion Combination of modified radical mastectomy and autologous skin grafting can achieve good clinical efficacy in the treatment of breast cancer.