不同基因作为竞争性内源RNA参与膀胱癌调控的研究进展

Research progress of different genes as ceRNA involved in bladder cancer regulation

竞争性内源RNA(competing endogenous RNA,ceRNA)是一种新的转录后RNA相互调控机制,越来越多的研究发现长链非编码RNA(long non-coding RNA,lncRNA)、环状RNA(circular RNA,circRNA)和假基因(pseudogenes)可以与微小RNA(microRNA,miRNA)竞争,影响靶RNA的稳定性或翻译,从而调控基因表达。近年来,不同基因作为ceRNA参与膀胱癌调控的研究已引起学者的广泛关注。为此,本文综述了lncRNA、circRNA和假基因作为ceRNA在膀胱癌中作用的研究进展,以及不同基因作为ceRNA调控膀胱癌的信号转导通路。从ceRNA分类的角度综述各类ceRNA在膀胱癌发生发展过程中的研究进展。

Competing endogenous RNA is a new RNA transcription regulatory mechanism.More and more studies have found that lncRNA,circRNA and pseudogenes that can compete with miRNA,influence the stability of the target RNA or translation,thus regulate gene expression.In recent years,the involvement of different genes as ceRNA in the regulation of bladder cancer has attracted extensive attention of researchers.To this end,this paper reviewed the research progress of lncRNA,circRNA and pseudogenes as ceRNA in bladder cancer,as well as the signal transduction pathways in bladder cancer regulated by different genes as ceRNA.The research progress of ceRNA in bladder cancer is reviewed from the perspective of ceRNA classification.