胆道闭锁诊断方法学研究进展

Research advances in diagnostic methodology of biliary atresia

胆道闭锁以肝内外胆道系统进行性纤维性闭锁为特点,造成严重的胆汁淤积和胆汁性肝硬化,是婴幼儿时期最常见的导致死亡的肝疾病。在胆道闭锁的治疗中,早期诊断及早期治疗是获得自体肝长期生存、改善临床转归及预后的关键因素。用于胆道闭锁的诊断学方法较多,各有优缺点,近年来一些新的诊断学方法和指标亦不断研发提出,本文对其进行综述分析。

Characterized by fibroatresia of intra/extrahepatic biliary system,biliary atresia(BA)causes severe cholestasis and biliary cirrhosis.It is the most common fatal liver disease in infants.Early diagnosis and early treatment are essential for achieving a long-term survival of autologous liver and improving clinical outcomes for BA.Many diagnostic methods are available for BA and each one has its own advantages and disadvantages.Recently some new diagnostic methods and biomarkers have been proposed.The diagnostic methodology of BA was summarized.