摘要
目的:探讨莪连颗粒治疗脾虚瘀热型慢性萎缩性胃炎癌前病变(PLGC)的临床疗效及对患者免疫功能的影响。方法:收集60例脾虚瘀热型PLGC患者,随机分为治疗组和对照组,治疗组予以莪连颗粒口服治疗,对照组予以胃黏膜保护剂(西药)治疗,持续12周。观察2组患者治疗前后症状总积分、主要症状积分和次要症状积分、胃黏膜病理组织学变化、血清CD3^(+)T、CD4^(+)T、CD8^(+)T、CD4^(+)T/CD8^(+)T变化情况。结果:治疗组患者主要症状积分优于对照组(P<0.05),次要症状积分与总积分均显著优于对照组(P<0.01);治疗组患者胃黏膜肠上皮化生、萎缩、慢性炎症、活动等病理变化均明显改善(P<0.01),异型增生改善也优于照组(P<0.05);治疗组总体临床疗效指数为91.34%,明显优于对照组(71.87%,P<0.01);治疗组患者CD3^(+)T、CD4^(+)T、CD4^(+)T/CD8^(+)T均有明显上升(P<0.01),CD8^(+)T水平明显降低(P<0.01)。结论:莪连颗粒治疗PLGC作用明显,可以改善脾虚瘀热型PLGC患者的临床症状和胃黏膜病理变化,提高患者机体免疫力。
Objective: To explore the clinical curative effect of Elian Granules on treatment of precancerous lesions of gastric cancer(PLGC) with spleen deficiency and heat stagnation pattern and its influence on immune function. Methods: Sixty patients with PLGC of spleen deficiency and heat stagnation pattern, were assigned to the treatment group and the control group by randomization method. Patients in the treatment group treated with Elian Granules, while those in the control group treated with western medicine, gastric mucosal protective agent. The therapeutic course for all was 12 weeks. The changes of total score, main symptom scores, secondary symptom score, histopathology, serum CD3^(+)T, CD4^(+)T, CD8^(+)T, CD4^(+)T/CD8^(+)T of the two groups were observed before and after treatment. Results: The main symptom score of the treatment group was better than that of the control group(P<0.05), the secondary symptom score and total score of the treatment group were significantly better than those of the control group(P<0.01);The pathological changes of intestinal metaplasia, atrophy, chronic inflammation and activity of gastric mucosa in the treatment group were significantly improved(P<0.01), and the improvement of dysplasia in the treatment group was also better than that in the control group(P<0.05). The overall clinical efficacy index of the treatment group was 91.34%, which was significantly better than that of the control group(71.87%,P<0.01). CD3^(+)T,CD4^(+)T, CD4^(+)T/CD8^(+)T all increased significantly(P<0.01), and the level of CD8^(+)T decreased significantly(P<0.01). Conclusion: Elian Granule has obvious effect in treating PLGC, which can improve the clinical symptoms and pathological changes of spleen deficiency and heat stagnation PLGC, and improve the immunity of patients.
作者
杨姗莹
庄羽骁
郭丽坤
丛军
岑戎
YANG Shanying;ZHUANG Yuxiao;GUO Likun;CONG Jun;CEN Rong(Department of Endoscopy,Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai,200021,China;Department of Gastroenterology,Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine)
出处
《中国中西医结合消化杂志》
CAS
2021年第9期638-641,共4页
Chinese Journal of Integrated Traditional and Western Medicine on Digestion
基金
上海市科委科研计划项目(No:18401971400)
上海中医药大学附属曙光医院“中西医结合研究专项”项目(No:SGZXY-201903)。
关键词
莪连颗粒
慢性萎缩性胃炎
脾虚瘀热
胃癌前病变
肠上皮化生
免疫功能
Elian Granules
chronic atrophic gastritis
spleen deficiency and heat stagnation
precancerous lesions of gastric cancer
intestinal metaplasia
immune function