肝细胞肝癌免疫分型的研究进展

Advances in immunophenotyping of hepatocellular carcinoma

目的总结基于肝细胞肝癌(HCC)肿瘤微环境的免疫分型的研究进展。方法检索近年HCC免疫分型的基础和临床研究相关文献并加以综述。结果基于肿瘤微环境,HCC能够被分为不同的免疫类型,不同的免疫类型显示出不同的免疫分子特征、免疫细胞浸润特点以及抗肿瘤的能力。同时HCC的免疫分型与患者的生存显著关联,已被证实可以更好地评估HCC患者的预后。根据HCC免疫微环境中相关的分子特征可以为免疫治疗提供用药方案指导。结论HCC免疫分型还在研究初期,对于患者的预后评估以及免疫治疗决策已初步显示出它的临床应用价值,是未来HCC个性化治疗的一个新思路。

Objective To summarize the research progress of hepatocellular carcinoma(HCC)based on tumor microenvironment immunophenotyping.Method The related literatures of basic and clinical studies on HCC immunophenotyping in the recent years were reviewed.Results HCC could be divided into different immunophenotypes based on tumor microenvironment,and it showed different immune molecular characteristics,immune cell infiltration characteristics,and anti-tumor ability.At the same time,the HCC immunophenotype was significantly associated with patients’survival and had been proved to be able to better evaluate the prognosis of HCC patients.According to the relevant molecular characteristics in the HCC immune microenvironment,it could provide guidance for the drug regimen of immunotherapy.Conclusion HCC immunophenotyping is still in the early stage of research,and its clinical application value has been preliminarily shown for the evaluation of patients’prognosis and immunotherapy decision-making,which is a new idea of individualized treatment of HCC in the future.