期刊文献+

无创检查在社区人群中筛查慢性肝病的研究进展 被引量:2

Research progress of non-invasive examination in the screening of chronic liver disease among the general community population
原文传递
导出
摘要 慢性肝病由于其发病的隐匿性,经常在出现失代偿事件后才就诊从而导致其死亡率居高不下。肝纤维化无创检查可以帮助慢性肝病患者早期诊断及干预。这些检查在医院人群中得到了广泛验证,但它们在社区人群中的价值尚不清楚。近年来,国外已有许多针对社区人群进行无创检查的研究,这些无创检查工具均能在社区人群中筛查出慢性肝病及肝硬化患者。进一步研究发现,针对具有肝病危险因素(大量饮酒、2型糖尿病、肥胖)的社区人群进行筛查,能更加高效地筛出社区人群中的慢性肝病患者。总之,相较于传统的依赖于异常肝功能化验的社区筛查,无创检查可以在社区人群中发现到大量之前未被发现的肝病患者。针对无创检查在社区人群中筛查慢性肝病展开讨论,以便于在我国寻找一条开创性的社区无创肝病筛查路径。 Due to its insidious nature,chronic liver disease usually only appears after a decompensating event,and delays in diagnosis lead to a high mortality.Non-invasive examination can help diagnose and intervene early stage liver fibrosis in patients with chronic liver disease.In a hospital population,this test has been widely used and appropriate;however,its value is unclear in the general community population.In recent years,there have been many studies on non-invasive examinations for foreign community populations.These non-invasive examination tools can screen patients with chronic liver disease and liver cirrhosis among the general community population.Further studies have found that screening community populations with liver disease risk factors(heavy alcohol consumption,type 2 diabetes mellitus,and obesity)can more efficiently screen out patients with chronic liver disease in the community population.In brief,these noninvasive examination can find a large number of previously undiscovered liver disease patients in the community population,compared to traditional community screening that rely on abnormal liver function testing.This paper discusses the non-invasive examination in the screening of chronic liver disease among the community population,so as to find a pioneering community non-invasive liver disease screening path for our country.
作者 杨诗晴 颜华东 Yang Shiqing;Yan Huadong(School of Medicine,Ningbo University,Ningbo 315211,China;Department of Infectious Disease,Shulan,Hangzhou,Hospital Affiliated to Zhejiang Shuren University Shulan International Medical College,Hangzhou 310022,China)
出处 《中华肝脏病杂志》 CSCD 北大核心 2021年第9期825-829,共5页 Chinese Journal of Hepatology
基金 2021年王宝恩肝纤维化研究基金(WBE2021030)。
关键词 无创检查 社区人群 慢性肝病 筛查路径 Noninvasive test Community population Chronic liver disease Screening pathway
  • 引文网络
  • 相关文献

参考文献2

二级参考文献24

  • 1龚涛,龚勇,邓东,叶孟良.重庆市流动农民工乙型病毒性肝炎感染现况研究[J].现代预防医学,2007,34(20):3842-3844. 被引量:8
  • 2Siddharth Verma,Donald Jensen,John Hart,Smruti R. Mohanty.Predictive value of ALT levels for non‐alcoholic steatohepatitis ( NASH ) and advanced fibrosis in non‐alcoholic fatty liver disease ( NAFLD )[J].Liver Int.2013(9)
  • 3Young Eun Chon,Kyu Sik Jung,Seung Up Kim,Jun Yong Park,Young Nyun Park,Do Young Kim,Sang Hoon Ahn,Chae Yoon Chon,Hye Won Lee,Yehyun Park,Kwang‐Hyub Han.Controlled attenuation parameter ( CAP ) for detection of hepatic steatosis in patients with chronic liver diseases: a prospective study of a native Korean population[J].Liver Int.2014(1)
  • 4Hyeon Chang Kim,Chung Mo Nam,Sun Ha Jee,Kwang Hyub Han,Dae Kyu Oh,Il S.Normal serum aminotransferase concentration and risk of mortality from liver diseases: prospective cohort study. British Medical Journal . 2004
  • 5JD Browning,JD Horton.Molecular mediators of hepatic steatosis and liver injury. The Journal of Clinical Investigation . 2004
  • 6W.‐C. Wu,C.‐Y. Wu,Y.‐J. Wang,H.‐H. Hung,H.‐I. Yang,W.‐Y. Kao,C.‐W. Su,J.‐C. Wu,W.‐L. Chan,H.‐C. Lin,F.‐Y. Lee,S.‐D. Lee.Updated thresholds for serum alanine aminotransferase level in a large‐scale population study composed of 34?346 subjects[J]. Aliment Pharmacol Ther . 2012 (6)
  • 7Stephen P. Casey,William W. Kemp,Catriona A. McLean,Duncan J. Topliss,Leon A. Adams,Stuart K. Roberts.A prospective evaluation of the role of transient elastography for the detection of hepatic fibrosis in type 2 diabetes without overt liver disease[J]. Scandinavian Journal of Gastroenterology . 2012 (7)
  • 8Beom KyungKim,Seung UpKim,Gi HongChoi,Woong KyuHan,Mi SungPark,Eun HyeKim,Jun YongPark,Do YoungKim,Jin SubChoi,Seung ChoulYang,Eun HeeChoi,KijunSong,Sang HoonAhn,Kwang‐HyubHan,Chae YoonChon.“Normal” liver stiffness values differ between men and women: A prospective study for healthy living liver and kidney donors in a native Korean population[J]. Journal of Gastroenterology and Hepatology . 2012 (4)
  • 9Ha Na Park,Dong Hyun Sinn,Geum‐Youn Gwak,Jee Eun Kim,Sang Youl Rhee,Sung June Eo,Yu Jin Kim,Moon Seok Choi,Joon Hyeok Lee,Kwang Cheol Koh,Seung Woon Paik,Byung Chul Yoo.Upper normal threshold of serum alanine aminotransferase in identifying individuals at risk for chronic liver disease[J]. Liver Int . 2012 (6)
  • 10Beom KyungKim,Kwang‐HyunHan,Sang HoonAhn.“Normal” range of alanine aminotransferase levels for Asian population[J]. Journal of Gastroenterology and Hepatology . 2011 (2)

共引文献64

同被引文献23

引证文献2

;
使用帮助 返回顶部