妇科三种常见恶性肿瘤患者弓形虫感染情况调查

Investigation of Toxoplasma gondii infection in patients with three common gynecological malignant tumors

目的探讨患有妇科3种常见恶性肿瘤人群中感染弓形虫的情况,探讨女性患有恶性肿瘤与感染弓形虫的相关性,为后续该类人群弓形虫感染防控提供依据。方法以2018年1月至2020年1月于中国医科大学附属盛京医院就诊的妇科恶性肿瘤(114例卵巢癌、107例宫颈癌和110例子宫内膜癌)患者作为研究组,以同时期的200例门诊健康体检正常的女性作为对照组。2组均采用酶联免疫吸附试验方法检测血清抗弓形虫IgM和IgG抗体。结果研究组患者的总体弓形虫感染率和总体血清抗弓形虫IgG抗体阳性率分别为26.89%(89/331)、26.28%(87/331),均比对照组的5.00%(10/200)高,差异有统计学意义(χ^(2)值为39.32、37.73,P<0.01)。研究组中卵巢癌、宫颈癌和子宫内膜癌3种不同肿瘤患者的血清中弓形虫IgG抗体的阳性率分别为28.07%(32/114)、25.23%(27/107)、25.45%(28/110),均高于对照组的5.00%(10/200),差异有统计学意义(χ^(2)值为32.26、27.32、28.00,均P<0.01)。结论免疫功能低下的妇科恶性肿瘤患者的弓形虫感染阳性率较高,应引起医务人员的足够重视,加强感染防控。

Objective To explore the infection of Toxoplasma gondii in patients with common gynecological malignancies and to explore the correlation between gynecological malignancies and Toxoplasma gondii infection,so as to provide basis for the prevention and control of Toxoplasma gondii infection in such population in the future.Methods Patients with gynecological malignancies(114 cases of ovarian cancer,107 cases of cervical cancer and 110 cases of endometrial cancer)treated in Shengjing Hospital of China Medical University from January 2018 to January 2020 were selected as the study group,and 200 women with normal physical examination during the same period were selected as the control group.Enzyme linked immunosorbent assay was used to detect serum anti Toxoplasma gondii IgM and IgG antibodies in the two groups.Results The overall Toxoplasma gondii infection rate and the overall serum anti-Toxoplasma gondii IgG antibody positive rate in the study group were 26.89%(89/331)and 26.28%(87/331),respectively,which were higher than 5.00%(10/200)of the control group,and the results were significantly different(χ^(2) values were 39.32,37.73,P<0.01).The positive rates of anti-Toxoplasma gondii IgG antibody in patients with ovarian cancer,cervical cancer and endometrial cancer of the study group were 28.07%(32/114),25.23%(27/107)and 25.45%(28/110),respectively,which were higher than those in the control group(5.00%,10/200)(χ^(2) values were 32.26,27.32,28.00,all P<0.01).Conclusions The positive rate of Toxoplasma gondii infection in gynecological malignant tumor patients with low immune function is high,which should be paid enough attention by medical staff to strengthen the prevention and control of infection.