生长激素缺乏症与非酒精性脂肪肝

Growth hormone deficiency and nonalcoholic fatty liver disease

生长激素除了具有促进生长的作用外,还对健康状态下的中间代谢有显著影响。但儿科医师通常关注于生长激素的促进生长作用,而容易忽视对代谢的影响。近年来,各种动物和人体(主要是成人)的研究以及儿童的临床报告一再表明生长激素缺乏症和脂肪肝之间存在联系。尽管目前尚缺乏涉及儿童的研究,儿科临床医师应不仅确保生长激素缺乏症的患者得到适当的治疗,而对于已经完成线性生长的青少年也应得到适当的过渡到成人的生长激素治疗。

In addition to its growth promoting role,growth hormone(GH)has a significant effect on intermediary metabolism in the healthy state.Pediatric practitioners usually focus on the growth promoting aspects of GH but overlook the effect on metabolism.In recent years,the clinical reports on various animal and human studies(in adults mainly)have repeatedly shown the association of GH deficiency(GHD)with fatty liver disease.Despite a lack of studies involving children,the pediatric clinician should ensure that not only patients with GHD are appropriately treated but adolescents even beyond the period of linear growth should be given appropriate GH therapy to ensure the transition to adulthood.