脑小血管病负荷水平在脑卒中后认知损害中的作用研究

The Role of Cerebral Small Vessel Disease Burden in the Pathogensis of Post-Stroke Congnitive Impaiment

脑卒中后认知损害是严重影响患者生活质量及生存时间的重要疾病,研究认为脑卒中前的脑小血管病负荷水平会直接关系到脑卒中后认知损害的发生概率、损害类型和严重程度。文中综述了脑白质高信号、脑微出血、脑萎缩、周围间隙扩大等脑卒中前脑小血管病负荷与脑卒中后认知损害之间的关联性研究,同时探讨了脑小血管病引起的脑卒中后认知损害的可能机制以及未来预防和治疗的研究方向。

Post-stroke cognitive impairment is an important disease that seriously affects the quality of life and survival time of patients.It is believed that the burden level of cerebral small vessel disease before stroke is directly related to the incidence,damage type and severity of post-stroke cognitive impairment.The relationship between pre-stroke small vessel disease burden and post-stroke cognitive impairment was reviewed,such as white matter hyperintensity,cerebral microbleeds,brain atrophy,peripheral space enlargement,and the possible mechanism,the research direction of prevention and treatment in the future were discussed.