骨膜细胞促进骨缺损修复的研究进展

Research updates of periosteal cells in bone defect repair

创伤、肿瘤等疾病导致的骨缺损在临床上十分常见,如何有效促进骨缺损修复仍是一大挑战。目前,越来越多的临床证据显示骨膜在促进骨缺损修复中起到了重要作用;一系列研究表明,缺损发生后,骨膜中的细胞可以动员迀移到骨缺损处,直接参与缺损修复。本文将对骨膜的发育来源、骨膜细胞在缺损修复中的生物学作用以及骨膜细胞群体的异质性加以综述,并对其临床应用前景以及未来研究方向加以展望。

Reconstruction of bone defects caused by trauma,tumor resection,and congenital disease remains a great challenge.Currently,the periosteum,a thin fibrous layer that covers the surface of the bone,has drawn increasing attention owing to its important role in bone repair.Upon injury,periosteal cells migrate into the bone defect and differentiate into osteocytes or chondrocytes to repair the defect.In this review,we briefly described the developmental origin of the periosteum and the reparative function of periosteal cells.Furthermore,we introduced the heterogeneity of periosteal cells involved in bone repair as well as the underlying mechanism.In the end,we highlighted future research directions of periosteal cells that might be beneficial for the reconstruction of craniofacial bone defects.