噬菌体裂解酶应用研究进展

Research progress in the application of bacteriophage lysin

近年来,随着抗生素的滥用,导致多重耐药性菌株出现的频率加快。因细菌感染导致死亡的人数逐年增多,人类健康面临巨大挑战,因此研制新型抗菌药物刻不容缓。噬菌体裂解酶因其高效的杀菌能力及高度的宿主专一性而成为新一代抗菌制剂的候选之一。其是一种细胞壁水解酶,在双链DNA噬菌体复制后期被合成,通过水解细胞壁肽聚糖上的化学键,从而裂解细菌细胞壁,释放出子代噬菌体。本文系统地介绍了噬菌体裂解酶的研究进展,为相关裂解酶抗菌药物的研发做出有益探索。

More recently,the frequency of multi-drug-resistant strains has sped up with the misuse of antibiotics.Since the number of deaths caused by bacterial infection is increasing year by year and human health is facing a substantial challenge,it is urgent to develop novel antibacterial drugs.Bacteriophage lysin is a type of protein which synthesized by double-stranded DNA bacteriophage at the late stage of genome replication.It can hydrolyze the peptidoglycan in the bacterial cell wall to release the progeny bacteriophage and kill the bacteria.Bacteriophage lysin is derived from bacteriophages and has a unique advantage of evolutionary selection.It is not only efficient and fast quickly kill multi-drug resistant bacteria,and it is not easy to cause bacteria to develop new drug resistance.Because of its highly efficient bactericidal capacity and high host specialization,bacteriophage lysin has become one candidate for a new generation of antibacterial agents.A review on the structure and mode of action of lysins and their application were presented.