胃癌的分子诊断与精准免疫治疗

Advances in molecular classification and precision immunotherapy for gastric cancer

胃癌在我国的发病率和死亡率均居高不下,免疫治疗有望改善其预后。胃癌分子分型作为胃癌分子诊疗的重要组成内容,是根据基因、免疫微环境等多个层面对胃癌患者进行精准分类,有助于筛选免疫治疗获益人群。本文就胃癌的分子诊断与免疫治疗的相关内容作一评述。

Gastric cancer(GC)is one of the malignant tumors with both high morbidity and mortality in China.Immunotherapy is expected to improve its prognosis.Molecular classification of GC based on multiple levels of assessment such as genes and tumor immune microenvironment(TiME),which can precisely screen the population with potential benefit from immunotherapy.It is helpful to make the treatment decision-making,and to further improve the efficacy of immunotherapy.