重复经颅磁刺激治疗对脑卒中后抑郁患者的疗效观察

Effect of repeated transcranial magnetic stimulation on patients with post-stroke depression

目的探讨重复经颅磁刺激(rTMS)治疗脑卒中后抑郁患者(PSD)的临床疗效。方法收集郑州市第九人民医院神经内科2019年7月至2021年2月期间门诊和住院部收治的PSD患者148例,根据患者是否接受rTMS治疗分为两组,未接受治疗组设为对照组(65例),接受治疗组设为观察组(83例)。治疗3个月后评价两组的汉密尔顿焦虑量表(HAMA)评分、汉密尔顿抑郁量表(HAMD)评分;进一步评估简易智力状态检查量表(MMSE)评分。结果入组初观察组和对照组基线资料比较差异无统计学意义(P>0.05);3个月后评估HAMA评分和HAMD评分观察组均低于对照组,差异有统计学意义(P>0.05),MMSE评分观察组高于对照组,差异有统计学意义(P>0.05)。结论rTMS可以减轻PSD患者的焦虑和抑郁症状,并提高其认知功能。

Objective To explore the clinical efficacy of repetitive transcranial magnetic stimulation(rTMS)in the treatment of patients with post-stroke depression(PSD).Methods 148 patients with PSD were collected and divided into two groups according to whether they received rTMS treatment in the outpatient and inpatient departments of Zhengzhou Ninth People's Hospital from July 2019 to February 2021.The untreated group was the control group(65 cases)and the treated group was the observation group(83 cases).After Three months after treatment,the scores of Hamilton Anxiety Scale(HAMA),Hamilton Depression Scale(HAMD)and Mini-mental State Examination(MMSE)were evaluated.Results At the beginning of enrollment,there was no significant difference between the two groups(P>0.05).Three months after treatment,HAMA and HAMD scores of the observation group were significantly lower than those in the control group(P>0.05),and their MMSE score was significantly higher than that in the control group(P>0.05).Conclusion rTMS can reduce anxiety and depression symptoms and improve cognitive function in patients with PSD.