免疫球蛋白糖基化在自身免疫性疾病中的作用

Role of immunoglobulin glycosylation in autoimmune diseases

糖基化是蛋白质生物合成过程中最重要的翻译后修饰之一,免疫球蛋白糖基化可通过调节抗体稳定性和影响其与不同FcγRs的相互作用,发挥抗炎和促炎活性。近年来,大量研究证实免疫球蛋白异常糖基化在自身免疫性疾病的发病中起到关键作用。其产物如糖链结构和/或糖基化蛋白,利用凝集素微阵列等技术进行检测,有望成为自身免疫性疾病新型血清标志物,在疾病的诊断、病情监测、预后评估以及治疗等方面具有广阔的应用前景。

Glycosylation is one of the most important post-translational modification in protein biosynthesis.Immunoglobulin glycosylation can exert anti-inflammatory or pro-inflammatory activity by regulating antibody stability and affecting its interaction with different FcγRs.In recent years,a large number of studies have confirmed that abnormal glycosylation of immunoglobulin plays a key role in the pathogenesis of autoimmune diseases.Its products,such as sugar chain structure or/and glycosylated proteins,can be detected by lectin microarray and other technologies,are expected to become new serum markers of autoimmune diseases.It has a broad application prospect in disease diagnosis,condition monitoring,prognosis evaluation and treatment.