CCR7与SELL在宫颈鳞状细胞癌中的表达及临床意义

Expression and clinical significance of CCR7 and SELL in cervical squamous cell carcinoma

目的探讨CCR7和SELL在宫颈鳞癌组织中的表达情况,并分析二者与宫颈鳞癌患者预后的关系。方法基于UALCAN数据库中305例宫颈鳞状细胞癌患者的mRNA表达谱数据,分析CCR7和SELL的表达情况。通过对不同分期的宫颈鳞状细胞癌患者的基因表达情况比较、CCR7和SELL基因共表达情况比较和生存曲线分析,讨论CCR7和SELL表达水平与患者的生存预后之间的联系。结果CCR7和SELL在宫颈鳞状细胞癌中的表达呈正相关(r=0.84),并且CCR7和SELL在宫颈鳞状细胞癌患者中的表达对预后具有显著性影响(P<0.05)。结论CCR7和SELL可以作为预测患者预后的潜在生物标志物和个体化治疗的潜在靶点。

Objective To investigate the expressions of CCR7 and SELL in cervical squamous cell carcinoma,and to analyze their correlation with the prognosis of patients with cervical squamous cell carcinoma.Methods Based on the mRNA expression profile of 305 cases of cervical squamous cell carcinoma in UALCAN database,the expression levels of CCR7 and SELL were analyzed.The correlation between CCR7 and SELL expression and survival prognosis were analyzed by comparing the gene expression,CCR7 and SELL gene co-expression and survival curve analysis of patients with cervical squamous cell carcinoma at different stages.Results The expression levels of CCR7 and SELL in patients with cervical squamous cell carcinoma were significantly higher than those in control group(P<0.05),moreover,the expression of CCR7 was positively correlated with that of SELL(Pearson correlation coefficient=0.84),and the expression levels of CCR7 and SELL in patients with cervical squamous cell carcinoma had significant effects on the prognosis of patients(P<0.05).Conclusion CCR7 and SELL can be regarded as potential biomarkers to predict the prognosis of patients and potential targets for individualized treatment.