急性髓系白血病中DNA甲基化异常及相关调控基因的研究进展

Advances in abnormal DNA methylation and related regulatory genes in AML

对急性髓系白血病(AML)全基因组测序及表观遗传学调控的研究,发现了一系列调控基因的突变导致DNA甲基化异常,从而导致AML的发生。其中,已有研究证实某些基因突变导致甲基化发生的作用机制,以及相对应的针对性治疗。这里我们讨论AML中导致DNA甲基化异常的调控基因和针对表观遗传调控的治疗进展。

From findings about genome sequencing and epigenetic regulation of acute myeloid leukemia(AML),a series of regulatory gene mutations was found leading to related aberrant DNA methylation,which probably lead to the occurrence of AML.Among them,some genes have been extensively studied about their mechanism of function and corresponding targeted therapy.In this paper,we will discuss regulatory genes that lead to aberrant DNA methylation and the treatment of epigenetic regulatory genes.