血清铁蛋白与子痫前期的关系研究

Study on the relationship between serum ferritin and preeclampsia

目的探讨血清铁蛋白与子痫前期发病及病情严重程度的关系。方法回顾性分析2018年11月至2019年10月空军军医大学第二附属医院进行产检的459例孕妇资料,根据是否发生子痫前期分为子痫前期组和对照组,再以妊娠期糖尿病(GDM)为分层因素分为GDM+子痫前期组、单纯子痫前期组、GDM组和正常组,比较各组孕早、中、晚期血清铁蛋白水平。结果子痫前期组和对照组孕早、中、晚期血清铁蛋白水平比较,差异无统计学意义(P>0.05)。而GDM+子痫前期组孕中期[(32.3±5.7)μg/L vs.(22.6±1.2)μg/L]、孕晚期[(41.6±7.8)μg/L vs.(24.9±1.0)μg/L]血清铁蛋白水平明显高于正常组,差异有统计学意义(P<0.05)。结论血清铁蛋白升高预示子痫前期的加重,但其并不是子痫前期的病因。

Objective To explore the relationship between serum ferritin and pathogenesis and severity of preeclampsia.Methods Retrospectively analyzed the data of 459 pregnant women who underwent maternity check-ups in the Second Affiliated Hospital of Air Force Medical University from November 2018 to October 2019.According to whether preeclampsia occurred,they were divided into the preeclampsia group and the control group.Using gestational diabetes mellitus(GDM)as a stratification factor,they were deeply divided into the GDM+preeclampsia group,the simple preeclampsia group,the GDM group and the normal group.Serum ferritin levels in the first,second and third trimester of each group were compared.Results There was no significant difference in serum ferritin levels between the preeclampsia group and the control group in the first,second and third trimester(P>0.05).In the GDM+preeclampsia group,the levels of serum ferritin in the second trimester[(32.3±5.7)μg/L vs.(22.6±1.2)μg/L]and the third trimester[(41.6±7.8)μg/L vs.(24.9±1.0)μg/L]were significantly higher than those in the normal group,the difference was statistically significant(P<0.05).Conclusion Elevated serum ferritin indicates the aggravation of preeclampsia,but it is not the etiology of preeclampsia.