免疫调节在骨组织愈合中的研究进展

Advances in immunomodulation in bone healing

当骨组织遭受创伤或植入骨替代材料后,不可避免地会引发组织内不同程度的免疫炎性反应。骨愈合微环境中炎症的发生、调控、转归对骨组织最终修复效果起着关键作用。骨微环境中的免疫细胞是机体先天性固有免疫反应的重要参与者,在局部微环境中对免疫细胞的主动、精确调控有利于急性炎症控制和协调成骨与破骨过程实现最佳的组织修复与再生效果。该文就骨愈合过程中微环境内参与固有免疫反应的主要免疫细胞(巨噬细胞、中性粒细胞、T细胞)的调控作用及其对成骨的影响进行综述。

When biomaterials were implanted for bone defects or bones suffered from injury,different immune inflammatory responses will be triggered in tissue healing progress inevitably.The occurrence,regulation and outcome of inflammation in the bone healing microenvironment play a key role on the final repair effect of bone tissue.Immune cells in the bone microenvironment are important participants in the body′s innate immune response.Active and precise regulation of immune cells in the local microenvironment is conducive to acute inflammation control and coordination of the process of bone formation and osteoclasts to achieve the best tissue repair and regeneration effects.This article reviews the regulation of the main immune cells(macrophages,neutrophils and T cells)involved in the innate immune response in the microenvironment during bone healing and their effects on bone formation.