失眠伴便秘型肠易激综合征患者睡眠特征及胃动素、生长抑素的临床观察

Clinical Observation of Sleep Characteristics,Motilin and Somatostatin in Patients with Insomnia and Constipation-Predominant Irritable Bowel Syndrome

目的:探讨失眠伴便秘型肠易激综合征患者睡眠特征及胃动素、生长抑素的临床情况。方法:选取2018年1月至2019年12月谷城县人民医院消化内科收治的失眠伴便秘型肠易激综合征患者32例作为观察组,另选取同期于本院体检健康的志愿者32例作为对照组。用多导睡眠仪进行24 h全天候监测,并检测胃动素和生长抑素水平。结果:观察组的记录时间、睡眠潜伏期长于对照组,睡眠时间、慢波睡眠时间和快速动眼(REM)潜伏期、REM时间短于对照组,睡眠效率低于对照组,胃动素及生长抑素水平高于对照组,差异有统计学意义(P<0.05)。结论:失眠伴便秘型肠易激综合征(IBS)患者的睡眠潜伏期长,睡眠效率低,体内胃动素、生长抑素水平高。

Objective:To investigate the sleep characteristics and the clinical situation of motilin and somatostatin in patients with insomnia and constipation irritable bowel syndrome.Methods:A total of 32 patients with insomnia and constipation irritable bowel syndrome treated in the Department of Gastroenterology of Gucheng County People′s Hospital from January 2018 to December 2019 were selected as the observation group,and 32 healthy volunteers in our hospital during the same period were selected as the control group.Polysomnography was used for 24-hour all-weather monitoring,and the levels of motilin and somatostatin were detected.Results:The recording time and sleep latency of the observation group were longer than those of the control group,and the sleep time,slow wave sleep time,rapid eye movement(REM)latency and REM time were shorter than those of the control group.The sleep efficiency was lower than that of the control group,and the levels of motilin and somatostatin were higher than those of the control group(P<0.05).Conclusion:Patients with insomnia and constipation irritable bowel syndrome(IBS)have long sleep latency,low sleep efficiency and high levels of motilin and somatostatin.