睡眠呼吸暂停低通气综合征与维生素D关系的研究进展

Research Progress on the Relationship between Sleep Apnea Hypopnea Syndrome and Vitamin D

睡眠呼吸暂停低通气综合征(OSAHS)是常见的睡眠障碍,可以导致全身多系统功能障碍及代谢的异常,严重者可威胁生命。维生素D是一种脂溶性维生素,在体内不仅参与钙磷代谢调节过程,还参与了越来越多的生理机制,包括睡眠、能量代谢、免疫调节、细胞增殖分化等。近年来有大量研究显示:OSAHS患者血清维生素D水平较正常人低,随疾病的严重程度逐渐加重,且2种疾病都具有很多相同的危险因素,都与肥胖、冬季、运动减少有关,都可以引起全身多系统疾病,因此OSAHS与低血清维生素D水平二者是否具有相关性,可能机制是什么,是本文讨论的重点。本文系统地回顾了国内外相关文献,主要就OSAHS对维生素D影响的研究现状及可能的机制做一综述,为将来OSAHS诊断、治疗提供新的思路。

Sleep apnea hyponea syndrome(OSAHS)is a common sleep disorder.It can lead to multi-system dysfunction and metabolic abnormalities.In severe cases,it can be life-threatening.Vitamin D is a fat-soluble vitamin,which not only participates in the regulation of calcium and phosphorus metabolism in the body,but also participates in a growing number of physiological mechanisms,including sleep,energy metabolism,immune regulation,cell proliferation and differentiation.In recent years a large number of research shows that the OSAHS patients serum vitamin D level was lower than those of normal people,and gradually increase the severity of the disease.Both diseases have many of the same risk factors,which are related to obesity,winter and less exercise,and can cause systemic diseases.Whether there is a correlation between the two,what is the possible mechanism,is the focus of this paper.In this paper,through a systematic review of the relevant literature at home and abroad,we mainly review the research status and possible mechanism of the effect of OSAHS on vitamin D,so as to provide new ideas for the diagnosis and treatment of OSAHS in the future.