铁死亡在心血管疾病中的研究进展

Research progress of iron death in cardiovascular disease

铁死亡是一种铁依赖的新型细胞程序性死亡方式,它是由于细胞铁含量过载诱发的脂肪酸脂质过氧化增加和活性氧簇的蓄积引起的细胞死亡。铁死亡与肿瘤、神经退行性疾病、代谢性疾病、老年化疾病等多种重大疾病发生发展密切相关。在心肌病、心肌梗死、心力衰竭、冠状动脉粥样硬化、心肌缺血再灌注损伤、糖尿病心肌病等多种疾病过程都有铁死亡的参与。本文对铁死亡在心血管疾病多种病理过程中的可能机制进行简要综述,有助于提高对铁死亡在心血管疾病中的认识。

Iron death is a new type of iron dependent programmed cell death,which is caused by the increase of fatty acid lipid peroxidation and the accumulation of reactive oxygen species induced by cell iron overload.Iron death is closely related to the occurrence and development of many major diseases such as tumor,neurodegenerative disease,metabolic disease and aging disease.Iron death is involved in many disease processes such as cardiomyopathy,myocardial infarction,heart failure,coronary atherosclerosis,myocardial ischemia-reperfusion injury,and diabetic cardiomyopathy.In this paper,the possible mechanisms of iron death in various pathological processes of cardiovascular disease are reviewed,which will help to improve understanding of iron death in cardiovascular disease.