胍丁胺与糖脂代谢

Agmatine and glycolipid metabolism

糖脂代谢异常及其所诱发的各种疾病的患病率逐年上升,已成为当今威胁人类健康的常见问题。寻找更为有效的预防和治疗与糖脂代谢异常相关疾病的方法已成为一个亟待解决的问题。胍丁胺(agmatine)是一种广泛存在于哺乳动物体内的多胺类物质,是L-精氨酸在精氨酸脱羧酶作用下脱羧基后的代谢产物,因此也被称为脱羧精氨酸。目前已发现其具有多种生物学作用。既往研究认为胍丁胺在糖尿病鼠中具有抗糖尿病的作用,不但可以缓解胰岛素抵抗,而且可以刺激胰岛β细胞分泌胰岛素,从而降低血糖。胍丁胺也可通过调节脂质代谢和脂肪酸的氧化等在脂代谢异常及其相关疾病中发挥积极作用。

The prevalence of abnormal glucose and lipid metabolism and its relevant diseases has increased year by year,and it has become a problem that threatens human health.Therefore,finding a more effective way to prevent and treat diseases related to abnormal glucose and lipid metabolism has become an urgent public problem.Agmatine is a polyamine substance which widely presents in mammals.It is a metabolite produced by decarboxylation of L-arginine under the action of arginine decarboxylase,hence also known as decarboxylated arginine.Its biological effects have been confirmed.Previous studies have shown that agmatine possesses anti-diabetic effects in diabetic animals.Agmatine not only increases the insulin secretion formβ-pancreatic cells to inhibit the hyperglycemia,but also attenuates insulin resistance in rats.Agmatine also plays a positive role in lipid metabolism disorders and related diseases by modulating lipid metabolism and fatty acid oxidation.